GALLERANI, E.; PROIETTO, D.; DALLAN, B.; CAMPAGNARO, M.; PACIFICO, S.; ALBANESE, V.; MARZOLA, E.; MARCONI, P.; CAPUTO, A.; APPAY, Victor; GAVIOLI, R.; NICOLI, F.

doi:10.3389/fimmu.2021.693054

Metadatos

Mostrar el registro completo del ítem

Licencia de uso del documento

Idioma

Article de revue

Este ítem está publicado en

Frontiers in Immunology. 2021, vol. 12

Resumen en inglés

Advanced age is associated with severe symptoms and death upon SARS-CoV-2 infection. Virus-specific CD8+ T-cell responses have shown to be protective toward critical COVID-19 manifestations, suggesting that suboptimal cellular immunity may contribute to the age-pattern of the disease. The induction of a CD8+ T-cell response against an emerging pathogen like SARS-CoV-2 relies on the activation of naive T cells. To investigate whether the primary CD8+ T-cell response against this virus is defective in advanced age, we used an in vitro approach to prime SARS-CoV-2-specific naive CD8+ T cells from healthy, unexposed donors of different age groups. Compared to younger adults, older individuals display a poor SARS-CoV-2-specific T-cell priming capacity in terms of both magnitude and quality of the response. In addition, older subjects recognize a lower number of epitopes. Our results implicate that immune aging is associated with altered primary SARS-CoV-2-specific CD8+ T-cell responses.< Leer menos

Palabras clave en inglés

CD8+ T cells

Cellular immunity

Epitopes

Immune aging

Naive T cells

Primary responses

SARS-CoV-2

Metadatos

Compartir este ítem

Licencia de uso del documento

Impaired Priming of SARS-CoV-2-Specific Naive CD8+ T Cells in Older Subjects

Idioma

Este ítem está publicado en

Resumen en inglés

Palabras clave en inglés

URI

DOI

Link to research data

Centros de investigación