Pathogenesis of cardiovascular events in BCR-ABL1-negative myeloproliferative neoplasms.
Language
EN
Article de revue
This item was published in
Leukemia. 2021-01-01, vol. 35, n° 4, p. 935-955
English Abstract
Thrombosis, both in arterial and venous territories, is the major complication of myeloproliferative neoplasms and is responsible for a high rate of morbidity and mortality. The currently accepted risk factors are an age ...Read more >
Thrombosis, both in arterial and venous territories, is the major complication of myeloproliferative neoplasms and is responsible for a high rate of morbidity and mortality. The currently accepted risk factors are an age over 60 years and a history of thrombosis. However, many complex mechanisms contribute to this increased prothrombotic risk, with involvement of all blood cell types, plasmatic factors, and endothelial cells. Besides, some cardiovascular events may originate from arterial vasospasm that could contribute to thrombotic complications. In this review, we discuss recent results obtained in mouse models in the light of data obtained from clinical studies. We emphasize on actors of thrombosis that are currently not targeted with current therapeutics but could be promising targets, i.e, neutrophil extracellular traps and vascular reactivity.Read less <
English Keywords
Animals
Biomarkers
Blood Cells
Blood Coagulation
Blood Coagulation Factors
Blood Vessels
Cardiovascular Diseases
Disease Management
Disease Models
Animal
Disease Susceptibility
Fusion Proteins
bcr-abl
Hemostasis
Humans
Mutation
Myeloproliferative Disorders
Risk Assessment
Risk Factors
Signal Transduction
Thrombosis