Pathogenesis of cardiovascular events in BCR-ABL1-negative myeloproliferative neoplasms.
| dc.rights.license | open | en_US |
| hal.structure.identifier | Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases | |
| dc.contributor.author | GUY, Alexandre | |
| dc.contributor.author | POISSON, Johanne | |
| hal.structure.identifier | Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases | |
| dc.contributor.author | JAMES, Chloe | |
| dc.date.accessioned | 2022-04-22T07:36:10Z | |
| dc.date.available | 2022-04-22T07:36:10Z | |
| dc.date.issued | 2021-01-01 | |
| dc.identifier.issn | 1476-5551 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/139899 | |
| dc.description.abstractEn | Thrombosis, both in arterial and venous territories, is the major complication of myeloproliferative neoplasms and is responsible for a high rate of morbidity and mortality. The currently accepted risk factors are an age over 60 years and a history of thrombosis. However, many complex mechanisms contribute to this increased prothrombotic risk, with involvement of all blood cell types, plasmatic factors, and endothelial cells. Besides, some cardiovascular events may originate from arterial vasospasm that could contribute to thrombotic complications. In this review, we discuss recent results obtained in mouse models in the light of data obtained from clinical studies. We emphasize on actors of thrombosis that are currently not targeted with current therapeutics but could be promising targets, i.e, neutrophil extracellular traps and vascular reactivity. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Animals | |
| dc.subject.en | Biomarkers | |
| dc.subject.en | Blood Cells | |
| dc.subject.en | Blood Coagulation | |
| dc.subject.en | Blood Coagulation Factors | |
| dc.subject.en | Blood Vessels | |
| dc.subject.en | Cardiovascular Diseases | |
| dc.subject.en | Disease Management | |
| dc.subject.en | Disease Models | |
| dc.subject.en | Animal | |
| dc.subject.en | Disease Susceptibility | |
| dc.subject.en | Fusion Proteins | |
| dc.subject.en | bcr-abl | |
| dc.subject.en | Hemostasis | |
| dc.subject.en | Humans | |
| dc.subject.en | Mutation | |
| dc.subject.en | Myeloproliferative Disorders | |
| dc.subject.en | Risk Assessment | |
| dc.subject.en | Risk Factors | |
| dc.subject.en | Signal Transduction | |
| dc.subject.en | Thrombosis | |
| dc.title.en | Pathogenesis of cardiovascular events in BCR-ABL1-negative myeloproliferative neoplasms. | |
| dc.title.alternative | Leukemia | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1038/s41375-021-01170-z | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio] | en_US |
| dc.identifier.pubmed | 33658660 | en_US |
| bordeaux.journal | Leukemia | en_US |
| bordeaux.page | 935-955 | en_US |
| bordeaux.volume | 35 | en_US |
| bordeaux.hal.laboratories | Biologie des maladies cardiovasculaires (BMC) - UMR 1034 | en_US |
| bordeaux.issue | 4 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | pubmed | |
| hal.export | false | |
| workflow.import.source | pubmed | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Leukemia&rft.date=2021-01-01&rft.volume=35&rft.issue=4&rft.spage=935-955&rft.epage=935-955&rft.eissn=1476-5551&rft.issn=1476-5551&rft.au=GUY,%20Alexandre&POISSON,%20Johanne&JAMES,%20Chloe&rft.genre=article |
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