Protein-Protein Interactions Focused Libraries for Drug Discovery
Langue
en
Autre document
Ce document a été publié dans
2013-09-16
Résumé en anglais
iPPI TreeTM library was designed using decision tree algorithm based on several molecular shape and functional group descriptors. iPPI AnalogsTM library was prepared by similarity search (ECFP4 fingerprints, minimum Tanimoto ...Lire la suite >
iPPI TreeTM library was designed using decision tree algorithm based on several molecular shape and functional group descriptors. iPPI AnalogsTM library was prepared by similarity search (ECFP4 fingerprints, minimum Tanimoto index is 0.4) with known active PPI inhibitors from TIMBAL database.< Réduire
Mots clés en anglais
Protein-protein interactions
cancer
inflammation
autoimmune diseases
diabetes
osteoporosis
infection
inhibitors
compound libraries
Origine
Importé de halUnités de recherche