Protein-Protein Interactions Focused Libraries for Drug Discovery
Language
en
Autre document
This item was published in
2013-09-16
English Abstract
iPPI TreeTM library was designed using decision tree algorithm based on several molecular shape and functional group descriptors. iPPI AnalogsTM library was prepared by similarity search (ECFP4 fingerprints, minimum Tanimoto ...Read more >
iPPI TreeTM library was designed using decision tree algorithm based on several molecular shape and functional group descriptors. iPPI AnalogsTM library was prepared by similarity search (ECFP4 fingerprints, minimum Tanimoto index is 0.4) with known active PPI inhibitors from TIMBAL database.Read less <
English Keywords
Protein-protein interactions
cancer
inflammation
autoimmune diseases
diabetes
osteoporosis
infection
inhibitors
compound libraries
Origin
Hal imported