MEYNARD, Joane; AMADO-BECKER, F.; TCHORELOFF, Pierre; MAZEL, Vincent

doi:10.1016/j.ijpharm.2021.121410

Métadonnées

Afficher la notice complète

Licence d’utilisation du document

MEYNARD, Joane

Institut de Mécanique et d'Ingénierie [I2M]

AMADO-BECKER, F.

TCHORELOFF, Pierre

Institut de Mécanique et d'Ingénierie [I2M]

Langue

Article de revue

Ce document a été publié dans

International Journal of Pharmaceutics. 2022-02-01, vol. 613, p. 121410

Résumé en anglais

Pharmaceutical tablets can be produced on different kinds of presses that may have very different compaction kinematics. Strain rate sensitivity (SRS) is thus an important property for the powders used to produce pharmaceutical tablets. Viscoelasticity is one of the aspects of the SRS and can be sometimes difficult to characterize. In this work, impulse excitation technique was used as an easy-to-implement method for characterizing viscoelasticity using the fact that this property induces damping which can be detected on resonance spectra as peak enlargements. A damping ratio, related to the first flexural vibration mode, was determined on impulse excitation frequency spectra using the half-power bandwidth method on tablets made with different products. This method made it possible to obtain reproducible results for the damping ratio. As viscoelasticity is not the only phenomena that can promote damping, tests were made in order to assess the influence of other parameters: viscoplasticity, porosity and tablet dimensions. Results indicated that the influence of these phenomena could be considered as negligible. Finally, the damping ratios determined were in good accordance with the known viscoelastic behavior of the studied products. This made it possible to confirm that impact resonance is an easy and quick way to characterize the viscoelastic nature of pharmaceutical tablets.< Réduire

Mots clés en anglais

Tablet

Compression

Viscoelasticity

Damping

Impact resonance

Strain rate sensitivity

Métadonnées

Partager cette publication !

Licence d’utilisation du document

Characterization of the viscoelasticity of pharmaceutical tablets using impulse excitation technique

Langue

Ce document a été publié dans

Résumé en anglais

Mots clés en anglais

URI

DOI

Lien vers les données de la recherche

Unités de recherche