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Characterization of the viscoelasticity of pharmaceutical tablets using impulse excitation technique

dc.rights.licenseopenen_US
hal.structure.identifierInstitut de Mécanique et d'Ingénierie [I2M]
dc.contributor.authorMEYNARD, Joane
dc.contributor.authorAMADO-BECKER, F.
hal.structure.identifierInstitut de Mécanique et d'Ingénierie [I2M]
dc.contributor.authorTCHORELOFF, Pierre
IDREF: 069233624
hal.structure.identifierInstitut de Mécanique et d'Ingénierie [I2M]
dc.contributor.authorMAZEL, Vincent
IDREF: 113057954
dc.date.accessioned2022-01-11T10:07:53Z
dc.date.available2022-01-11T10:07:53Z
dc.date.issued2022-02-01
dc.identifier.issn0378-5173en_US
dc.identifier.otherhttps://ars-els-cdn-com.docelec.u-bordeaux.fr/content/image/1-s2.0-S0378517321012163-mmc1.docxen_US
dc.identifier.urioai:crossref.org:10.1016/j.ijpharm.2021.121410
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/124348
dc.description.abstractEnPharmaceutical tablets can be produced on different kinds of presses that may have very different compaction kinematics. Strain rate sensitivity (SRS) is thus an important property for the powders used to produce pharmaceutical tablets. Viscoelasticity is one of the aspects of the SRS and can be sometimes difficult to characterize. In this work, impulse excitation technique was used as an easy-to-implement method for characterizing viscoelasticity using the fact that this property induces damping which can be detected on resonance spectra as peak enlargements. A damping ratio, related to the first flexural vibration mode, was determined on impulse excitation frequency spectra using the half-power bandwidth method on tablets made with different products. This method made it possible to obtain reproducible results for the damping ratio. As viscoelasticity is not the only phenomena that can promote damping, tests were made in order to assess the influence of other parameters: viscoplasticity, porosity and tablet dimensions. Results indicated that the influence of these phenomena could be considered as negligible. Finally, the damping ratios determined were in good accordance with the known viscoelastic behavior of the studied products. This made it possible to confirm that impact resonance is an easy and quick way to characterize the viscoelastic nature of pharmaceutical tablets.
dc.language.isoENen_US
dc.sourcecrossref
dc.subject.enTablet
dc.subject.enCompression
dc.subject.enViscoelasticity
dc.subject.enDamping
dc.subject.enImpact resonance
dc.subject.enStrain rate sensitivity
dc.title.enCharacterization of the viscoelasticity of pharmaceutical tablets using impulse excitation technique
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.ijpharm.2021.121410en_US
dc.subject.halSciences de l'ingénieur [physics]/Matériauxen_US
bordeaux.journalInternational Journal of Pharmaceuticsen_US
bordeaux.page121410en_US
bordeaux.volume613en_US
bordeaux.hal.laboratoriesInstitut de Mécanique et d’Ingénierie de Bordeaux (I2M) - UMR 5295en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionCNRSen_US
bordeaux.institutionINRAEen_US
bordeaux.institutionArts et Métiersen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcedissemin
hal.identifierhal-03520704
hal.version1
hal.date.transferred2022-01-11T10:10:31Z
hal.exporttrue
workflow.import.sourcedissemin
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=International%20Journal%20of%20Pharmaceutics&rft.date=2022-02-01&rft.volume=613&rft.spage=121410&rft.epage=121410&rft.eissn=0378-5173&rft.issn=0378-5173&rft.au=MEYNARD,%20Joane&AMADO-BECKER,%20F.&TCHORELOFF,%20Pierre&MAZEL,%20Vincent&rft.genre=article


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