Human γδ T cell sensing of AMPK-dependent metabolic tumor reprogramming through TCR recognition of EphA2
LARTIGUE, Lydia
Actions for OnCogenesis understanding and Target Identification in ONcology [ACTION]
Actions for OnCogenesis understanding and Target Identification in ONcology [ACTION]
MAHOUCHE, Isabelle
Actions for OnCogenesis understanding and Target Identification in ONcology [ACTION]
Actions for OnCogenesis understanding and Target Identification in ONcology [ACTION]
SOUBEYRAN, Isabelle
Actions for OnCogenesis understanding and Target Identification in ONcology [ACTION]
Actions for OnCogenesis understanding and Target Identification in ONcology [ACTION]
ROSSIGNOL, Rodrigue
Centre Génomique Fonctionnelle Bordeaux [Bordeaux] [CGFB]
Laboratoire Maladies Rares: Génétique et Métabolisme (Bordeaux) [U1211 INSERM/MRGM]
< Réduire
Centre Génomique Fonctionnelle Bordeaux [Bordeaux] [CGFB]
Laboratoire Maladies Rares: Génétique et Métabolisme (Bordeaux) [U1211 INSERM/MRGM]
Langue
EN
Article de revue
Ce document a été publié dans
Science Immunology. 2021-07-30, vol. 6, n° 61
Résumé en anglais
Human γδ T cells play a critical role in surveillance against infection and cancer and use various mechanisms to sense metabolic changes associated with these assaults. Harly et al. describe a role for the stress ligand ...Lire la suite >
Human γδ T cells play a critical role in surveillance against infection and cancer and use various mechanisms to sense metabolic changes associated with these assaults. Harly et al. describe a role for the stress ligand ephrin type-A receptor 2 (EphA2), which is up-regulated on cancer cells and is recognized by the human Vγ9Vδ1 T cell receptor (TCR) together with ephrin A. EphA2 up-regulation was mediated by metabolic changes in cancer cells caused by AMP-activated protein kinase (AMPK) activity. Increased coexpression of EphA2 and AMPK in tumor tissues was also linked to greater T cell infiltration in human colorectal cancer tissue. These findings suggest that human γδ T cells can sense changes in stress ligands and trigger responses caused by metabolic changes associated with infection or cancer.< Réduire
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