HARLY, Christelle; JOYCE, Stephen Paul; DOMBLIDES, Charlotte; BACHELET, Thomas; PITARD, Vincent; MANNAT, Charlotte; PAPPALARDO, Angela; COUZI, Lionel; NETZER, Sonia; MASSARA, Layal; OBRE, Emilie; HAWCHAR, Omar; LARTIGUE, Lydia; CLAVEROL, Stephane; CANO, Carla; MOREAU, Jean-Francois; MAHOUCHE, Isabelle; SOUBEYRAN, Isabelle; ROSSIGNOL, Rodrigue; VIOLLET, Benoit; WILLCOX, Carrie R.; MOHAMMED, Fiyaz; WILLCOX, Benjamin E.; FAUSTIN, Benjamin; DECHANET-MERVILLE, Julie

doi:10.1126/sciimmunol.aba9010

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HARLY, Christelle
Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]

JOYCE, Stephen Paul

DOMBLIDES, Charlotte

Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]

HARLY, Christelle
Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]

JOYCE, Stephen Paul

DOMBLIDES, Charlotte

Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]

BACHELET, Thomas
Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]

PITARD, Vincent
Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]

MANNAT, Charlotte
Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]

PAPPALARDO, Angela
Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]

COUZI, Lionel
Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]

NETZER, Sonia
Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]

MASSARA, Layal

Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]

OBRE, Emilie
Centre Génomique Fonctionnelle Bordeaux [Bordeaux] [CGFB]

HAWCHAR, Omar
Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]

LARTIGUE, Lydia
Actions for OnCogenesis understanding and Target Identification in ONcology [ACTION]

CLAVEROL, Stephane
Centre Génomique Fonctionnelle Bordeaux [Bordeaux] [CGFB]

CANO, Carla

MOREAU, Jean-Francois
Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]

MAHOUCHE, Isabelle
Actions for OnCogenesis understanding and Target Identification in ONcology [ACTION]

SOUBEYRAN, Isabelle
Actions for OnCogenesis understanding and Target Identification in ONcology [ACTION]

ROSSIGNOL, Rodrigue

Centre Génomique Fonctionnelle Bordeaux [Bordeaux] [CGFB]
Laboratoire Maladies Rares: Génétique et Métabolisme (Bordeaux) [U1211 INSERM/MRGM]

Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]

DECHANET-MERVILLE, Julie

Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]

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Science Immunology. 2021-07-30, vol. 6, n° 61

Résumé en anglais

Human γδ T cells play a critical role in surveillance against infection and cancer and use various mechanisms to sense metabolic changes associated with these assaults. Harly et al. describe a role for the stress ligand ephrin type-A receptor 2 (EphA2), which is up-regulated on cancer cells and is recognized by the human Vγ9Vδ1 T cell receptor (TCR) together with ephrin A. EphA2 up-regulation was mediated by metabolic changes in cancer cells caused by AMP-activated protein kinase (AMPK) activity. Increased coexpression of EphA2 and AMPK in tumor tissues was also linked to greater T cell infiltration in human colorectal cancer tissue. These findings suggest that human γδ T cells can sense changes in stress ligands and trigger responses caused by metabolic changes associated with infection or cancer.< Réduire

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https://oskar-bordeaux.fr/handle/20.500.12278/112879

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http://dx.doi.org/10.1126/sciimmunol.aba9010

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Human γδ T cell sensing of AMPK-dependent metabolic tumor reprogramming through TCR recognition of EphA2

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Human γδ T cell sensing of AMPK-dependent metabolic tumor reprogramming through TCR recognition of EphA2

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