NUZZACI, Danae; CANSELL, Celine; LIENARD, Fabienne; NEDELEC, Emmanuelle; BEN FRADJ, Selma; CASTEL, Julien; FOPPEN, Ewout; DENIS, Raphael G. P.; GROUSELLE, Dominique; LADERRIERE, Amelie; LEMOINE, Aleth; MATHOU, Alexia; TOLLE, Virginie; HEURTAUX, Tony; FIORAMONTI, Xavier; AUDINAT, Etienne; PENICAUD, Luc; NAHON, Jean-Louis; ROVERE, Carole; BENANI, Alexandre

doi:10.1016/j.celrep.2020.02.029

Langue

Article de revue

Ce document a été publié dans

Cell Reports. 2020-03, vol. 30, n° 9, p. 3067-3078.e5

Résumé en anglais

Mechanistic studies in rodents evidenced synaptic remodeling in neuronal circuits that control food intake. However, the physiological relevance of this process is not well defined. Here, we show that the firing activity of anorexigenic POMC neurons located in the hypothalamus is increased after a standard meal. Postprandial hyperactivity of POMC neurons relies on synaptic plasticity that engages pre-synaptic mechanisms, which does not involve structural remodeling of synapses but retraction of glial coverage. These functional and morphological neuroglial changes are triggered by postprandial hyperglycemia. Chemogenetically induced glial retraction on POMC neurons is sufficient to increase POMC activity and modify meal patterns. These findings indicate that synaptic plasticity within the melanocortin system happens at the timescale of meals and likely contributes to short-term control of food intake. Interestingly, these effects are lost with a high-fat meal, suggesting that neuroglial plasticity of POMC neurons is involved in the satietogenic properties of foods.< Réduire

Mots clés en anglais

Hypothalamus

Plasticity

Energy homeostasis

Obesity

Melanocortin system

Pro-opiomelanocortin neurons

Astrocytes

Food intake

Satiety

URI

https://oskar-bordeaux.fr/handle/20.500.12278/112387

DOI

http://dx.doi.org/10.1016/j.celrep.2020.02.029

Project ANR

Contrôle nerveux de la prise alimentaire et du métabolisme par une molécule neurale d'adhésion cellulaire
ISITE " BFC
Réseau d'Innovation sur les Voies de Signalisation en Sciences de la Vie - ANR-11-LABX-0028

Unités de recherche

NutriNeuro (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286

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Postprandial hyperglycemia stimulates neuroglial plasticity in hypothalamic POMC neurons after a balanced meal