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Postprandial hyperglycemia stimulates neuroglial plasticity in hypothalamic POMC neurons after a balanced meal

dc.rights.licenseopenen_US
dc.contributor.authorNUZZACI, Danae
dc.contributor.authorCANSELL, Celine
dc.contributor.authorLIENARD, Fabienne
dc.contributor.authorNEDELEC, Emmanuelle
dc.contributor.authorBEN FRADJ, Selma
dc.contributor.authorCASTEL, Julien
dc.contributor.authorFOPPEN, Ewout
dc.contributor.authorDENIS, Raphael G. P.
dc.contributor.authorGROUSELLE, Dominique
dc.contributor.authorLADERRIERE, Amelie
dc.contributor.authorLEMOINE, Aleth
dc.contributor.authorMATHOU, Alexia
dc.contributor.authorTOLLE, Virginie
dc.contributor.authorHEURTAUX, Tony
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorFIORAMONTI, Xavier
dc.contributor.authorAUDINAT, Etienne
dc.contributor.authorPENICAUD, Luc
dc.contributor.authorNAHON, Jean-Louis
dc.contributor.authorROVERE, Carole
dc.contributor.authorBENANI, Alexandre
dc.date.accessioned2021-09-24T13:35:14Z
dc.date.available2021-09-24T13:35:14Z
dc.date.issued2020-03
dc.identifier.issn2211-1247en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/112387
dc.description.abstractEnMechanistic studies in rodents evidenced synaptic remodeling in neuronal circuits that control food intake. However, the physiological relevance of this process is not well defined. Here, we show that the firing activity of anorexigenic POMC neurons located in the hypothalamus is increased after a standard meal. Postprandial hyperactivity of POMC neurons relies on synaptic plasticity that engages pre-synaptic mechanisms, which does not involve structural remodeling of synapses but retraction of glial coverage. These functional and morphological neuroglial changes are triggered by postprandial hyperglycemia. Chemogenetically induced glial retraction on POMC neurons is sufficient to increase POMC activity and modify meal patterns. These findings indicate that synaptic plasticity within the melanocortin system happens at the timescale of meals and likely contributes to short-term control of food intake. Interestingly, these effects are lost with a high-fat meal, suggesting that neuroglial plasticity of POMC neurons is involved in the satietogenic properties of foods.
dc.description.sponsorshipContrôle nerveux de la prise alimentaire et du métabolisme par une molécule neurale d'adhésion cellulaireen_US
dc.description.sponsorshipISITE " BFCen_US
dc.description.sponsorshipRéseau d'Innovation sur les Voies de Signalisation en Sciences de la Vie - ANR-11-LABX-0028en_US
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enHypothalamus
dc.subject.enPlasticity
dc.subject.enEnergy homeostasis
dc.subject.enObesity
dc.subject.enMelanocortin system
dc.subject.enPro-opiomelanocortin neurons
dc.subject.enAstrocytes
dc.subject.enFood intake
dc.subject.enSatiety
dc.title.enPostprandial hyperglycemia stimulates neuroglial plasticity in hypothalamic POMC neurons after a balanced meal
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.celrep.2020.02.029en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed32130907en_US
bordeaux.journalCell Reportsen_US
bordeaux.page3067-3078.e5en_US
bordeaux.volume30en_US
bordeaux.hal.laboratoriesNutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.issue9en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAEen_US
bordeaux.teamPsychoneuroimmunologie et Nutrition: Approches expérimentales et cliniquesen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDAgence Nationale de la Rechercheen_US
bordeaux.identifier.funderIDConseil régional de Bourgogne-Franche-Comtéen_US
bordeaux.identifier.funderIDFondation pour la Recherche Médicaleen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Cell%20Reports&rft.date=2020-03&rft.volume=30&rft.issue=9&rft.spage=3067-3078.e5&rft.epage=3067-3078.e5&rft.eissn=2211-1247&rft.issn=2211-1247&rft.au=NUZZACI,%20Danae&CANSELL,%20Celine&LIENARD,%20Fabienne&NEDELEC,%20Emmanuelle&BEN%20FRADJ,%20Selma&rft.genre=article


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