LETONDOR, Anne; BUAUD, Benjamin; VAYSSE, Carole; RICHARD, Emmanuel; LAYE, Sophie; PALLET, Veronique; ALFOS, Serge

doi:10.3389/fnagi.2016.00103

LETONDOR, Anne
Nutrition et Neurobiologie intégrée [NutriNeuro]

BUAUD, Benjamin

VAYSSE, Carole

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Article de revue

Ce document a été publié dans

Frontiers in Aging Neuroscience. 2016-05-09, vol. 8, p. 16 p.

Résumé en anglais

Studies suggest that eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and vitamin A are critical to delay aged-related cognitive decline. These nutrients regulate gene expression in the brain by binding to nuclear receptors such as the retinoid X receptors (RXRs) and the retinoic acid receptors (RARs). Moreover, EPA/DHA and retinoids activate notably kinase signaling pathways such as AKT or MAPK, which includes ERK1/2. This suggests that these nutrients may modulate brain function in a similar way. Therefore, we investigated in middle-aged rats the behavioral and molecular effects of supplementations with EPA/DHA and vitamin A alone or combined. 18-month-old rats exhibited reference and working memory deficits in the Morris water maze, associated with a decrease in serum vitamin A and hippocampal EPA/DHA contents. RAR?, RXR?, and RXR? mRNA expression and CAMKII, AKT, ERK1/2 expression were decreased in the hippocampus of middle-aged rats. A combined EPA/DHA and vitamin A supplementation had a beneficial additive effect on reference memory but not in working memory in middle-aged rats, associated with an alleviation of the age-related decrease in RXR?, CAMKII, AKT, and ERK1 expression in the hippocampus. This study provides a new combined nutritional strategy to delay brain aging.< Réduire

Mots clés en anglais

n-3 long-chain PUFA

Hippocampus

Kinases

Retinoid receptors

Memory

Vitamin A

URI

https://oskar-bordeaux.fr/handle/20.500.12278/112351

DOI

http://dx.doi.org/10.3389/fnagi.2016.00103

Unités de recherche

NutriNeuro (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286

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EPA/DHA and vitamin A supplementation improves spatial memory and alleviates the age-related decrease in hippocampal RXR? and kinase expression in rats

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Résumé en anglais

Mots clés en anglais

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