EPA/DHA and vitamin A supplementation improves spatial memory and alleviates the age-related decrease in hippocampal RXR? and kinase expression in rats
| dc.rights.license | open | en_US |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | LETONDOR, Anne | |
| dc.contributor.author | BUAUD, Benjamin | |
| dc.contributor.author | VAYSSE, Carole | |
| dc.contributor.author | RICHARD, Emmanuel | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | LAYE, Sophie
ORCID: 0000-0002-3843-1012 IDREF: 11366883X | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | PALLET, Veronique
ORCID: 0000-0002-9078-3269 IDREF: 066841763 | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | ALFOS, Serge | |
| dc.date.accessioned | 2021-09-23T10:51:59Z | |
| dc.date.available | 2021-09-23T10:51:59Z | |
| dc.date.issued | 2016-05-09 | |
| dc.identifier.issn | 1663-4365 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/112351 | |
| dc.description.abstractEn | Studies suggest that eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and vitamin A are critical to delay aged-related cognitive decline. These nutrients regulate gene expression in the brain by binding to nuclear receptors such as the retinoid X receptors (RXRs) and the retinoic acid receptors (RARs). Moreover, EPA/DHA and retinoids activate notably kinase signaling pathways such as AKT or MAPK, which includes ERK1/2. This suggests that these nutrients may modulate brain function in a similar way. Therefore, we investigated in middle-aged rats the behavioral and molecular effects of supplementations with EPA/DHA and vitamin A alone or combined. 18-month-old rats exhibited reference and working memory deficits in the Morris water maze, associated with a decrease in serum vitamin A and hippocampal EPA/DHA contents. RAR?, RXR?, and RXR? mRNA expression and CAMKII, AKT, ERK1/2 expression were decreased in the hippocampus of middle-aged rats. A combined EPA/DHA and vitamin A supplementation had a beneficial additive effect on reference memory but not in working memory in middle-aged rats, associated with an alleviation of the age-related decrease in RXR?, CAMKII, AKT, and ERK1 expression in the hippocampus. This study provides a new combined nutritional strategy to delay brain aging. | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.subject.en | n-3 long-chain PUFA | |
| dc.subject.en | Hippocampus | |
| dc.subject.en | Kinases | |
| dc.subject.en | Retinoid receptors | |
| dc.subject.en | Memory | |
| dc.subject.en | Vitamin A | |
| dc.title.en | EPA/DHA and vitamin A supplementation improves spatial memory and alleviates the age-related decrease in hippocampal RXR? and kinase expression in rats | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.3389/fnagi.2016.00103 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
| dc.identifier.pubmed | 27242514 | en_US |
| bordeaux.journal | Frontiers in Aging Neuroscience | en_US |
| bordeaux.page | 16 p. | en_US |
| bordeaux.volume | 8 | en_US |
| bordeaux.hal.laboratories | NutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INRAE | en_US |
| bordeaux.team | Psychoneuroimmunologie et Nutrition: Approches expérimentales et cliniques | en_US |
| bordeaux.team | Nutrition, mémoire et glucocorticoïdes | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.identifier.funderID | Conseil Régional Aquitaine | en_US |
| bordeaux.identifier.funderID | Ministère de l'Agriculture, de l'Agroalimentaire et de la Forêt | en_US |
| bordeaux.identifier.funderID | Association Nationale de la Recherche et de la Technologie | en_US |
| hal.export | false | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Frontiers%20in%20Aging%20Neuroscience&rft.date=2016-05-09&rft.volume=8&rft.spage=16%20p.&rft.epage=16%20p.&rft.eissn=1663-4365&rft.issn=1663-4365&rft.au=LETONDOR,%20Anne&BUAUD,%20Benjamin&VAYSSE,%20Carole&RICHARD,%20Emmanuel&LAYE,%20Sophie&rft.genre=article |
