BOSCH BOUJU, Clementine; LARRIEU, Thomas; LINDERS, Louisa; MANZONI, Olivier; LAYE, Sophie

doi:10.1016/j.celrep.2016.06.082

Nutrition et Neurobiologie intégrée [NutriNeuro]

LARRIEU, Thomas
Nutrition et Neurobiologie intégrée [NutriNeuro]

LINDERS, Louisa
Nutrition et Neurobiologie intégrée [NutriNeuro]

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Article de revue

Ce document a été publié dans

Cell Reports. 2016-07-21, vol. 16, n° 5, p. 1237 - 1242

Résumé en anglais

Chronic social defeat stress (CSDS) is a clinically relevant model of mood disorders. The relationship between the CSDS model and a physiologically pertinent paradigm of synaptic plasticity is not known. Here, we found that cluster analysis of the emotional behavior states of mice exposed to CSDS allowed their segregation into anxious and non-anxious groups. Endocannabinoid-mediated spike-timing dependent plasticity (STDP) in the nucleus accumbens was attenuated in non-anxious mice and abolished in anxious mice. Anxiety-like behavior in stressed animals was specifically correlated with their ability to produce STDP. Pharmacological enhancement of 2-arachidonoyl glycerol (2-AG) signaling in the nucleus accumbens normalized the anxious phenotype and STDP in anxious mice. These data reveal that endocannabinoid modulation of synaptic efficacy in response to a naturalistic activity pattern is both a molecular correlate of behavioral adaptability and a crucial factor in the adaptive response to chronic stress.< Réduire

URI

https://oskar-bordeaux.fr/handle/20.500.12278/112350

DOI

http://dx.doi.org/10.1016/j.celrep.2016.06.082

Projet Européen

FP7-267196-MSCA-COFUND-AgreenSkills

Project ANR

Dépression et Nutrition - ANR-12-BSV4-0025

Unités de recherche

NutriNeuro (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286

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Endocannabinoid-Mediated Plasticity in Nucleus Accumbens Controls Vulnerability to Anxiety after Social Defeat Stress