Alzheimer's disease and Helicobacter pylori infection: inflammation from stomach to brain?
| dc.rights.license | open | en_US |
| hal.structure.identifier | Bordeaux Research In Translational Oncology [Bordeaux] [BaRITOn] | |
| dc.contributor.author | ALBARET, Guillaume | |
| hal.structure.identifier | Bordeaux Research In Translational Oncology [Bordeaux] [BaRITOn] | |
| dc.contributor.author | SIFRE, Elodie | |
| hal.structure.identifier | Bordeaux Research In Translational Oncology [Bordeaux] [BaRITOn] | |
| dc.contributor.author | FLOCH, Pauline | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | LAYE, Sophie
ORCID: 0000-0002-3843-1012 IDREF: 11366883X | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | AUBERT, Agnes | |
| hal.structure.identifier | Bordeaux Research In Translational Oncology [Bordeaux] [BaRITOn] | |
| dc.contributor.author | DUBUS, Pierre | |
| hal.structure.identifier | Bordeaux Research In Translational Oncology [Bordeaux] [BaRITOn] | |
| dc.contributor.author | AZZI-MARTIN, Lamia | |
| hal.structure.identifier | Bordeaux Research In Translational Oncology [Bordeaux] [BaRITOn] | |
| dc.contributor.author | GIESE, Alban | |
| hal.structure.identifier | Bordeaux Research In Translational Oncology [Bordeaux] [BaRITOn] | |
| dc.contributor.author | SALLES, Nathalie | |
| hal.structure.identifier | Bordeaux Research In Translational Oncology [Bordeaux] [BaRITOn] | |
| dc.contributor.author | MEGRAUD, Francis | |
| hal.structure.identifier | Bordeaux Research In Translational Oncology [Bordeaux] [BaRITOn] | |
| dc.contributor.author | VARON, Christine | |
| hal.structure.identifier | Bordeaux Research In Translational Oncology [Bordeaux] [BaRITOn] | |
| dc.contributor.author | LEHOURS, Philippe | |
| hal.structure.identifier | Bordeaux Research In Translational Oncology [Bordeaux] [BaRITOn] | |
| dc.contributor.author | ROUBAUD-BAUDRON, Claire | |
| dc.date.accessioned | 2021-09-22T12:10:02Z | |
| dc.date.available | 2021-09-22T12:10:02Z | |
| dc.date.issued | 2020 | |
| dc.identifier.issn | 1387-2877 (Print) 1875-8908 (Online) | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/112323 | |
| dc.description.abstractEn | Despite extensive research, the origin of Alzheimer's disease (AD) remains unknown. The role of infectious pathogens has recently emerged. Epidemiological studies have shown that Helicobacter pylori infection increases the risk of developing AD. We hypothesized that H. pylon-induced gastritis may be associated with a systemic inflammation and finally neuroinflammation. C57BL/6 mice were infected with H. pylori (n= 15) or Helicobacter felis (n= 13) or left uninfected (n = 9) during 18 months. Gastritis, amyloid deposition, astroglial and microglial cell area, and systemic and brain cytokines were assessed. The infection (H. felis>H. pylori) induced a severe gastritis and an increased neuroinflammation but without brain amyloid deposition or systemic inflammation. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Alzheimer's disease | |
| dc.subject.en | dementia | |
| dc.subject.en | gastric inflammation | |
| dc.subject.en | GFAP | |
| dc.subject.en | Helicobacter infection | |
| dc.subject.en | iba-1 | |
| dc.subject.en | neuroinflammation | |
| dc.title.en | Alzheimer's disease and Helicobacter pylori infection: inflammation from stomach to brain? | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.3233/JAD-190496 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
| dc.identifier.pubmed | 31868664 | en_US |
| bordeaux.journal | Journal of Alzheimer's Disease | en_US |
| bordeaux.page | 801-809 | en_US |
| bordeaux.volume | 73 | en_US |
| bordeaux.hal.laboratories | NutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286 | en_US |
| bordeaux.issue | 2 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INRAE | en_US |
| bordeaux.team | Psychoneuroimmunologie et Nutrition: Approches expérimentales et cliniques | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.export | false | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Alzheimer's%20Disease&rft.date=2020&rft.volume=73&rft.issue=2&rft.spage=801-809&rft.epage=801-809&rft.eissn=1387-2877%20(Print)%201875-8908%20(Online)&rft.issn=1387-2877%20(Print)%201875-8908%20(Online)&rft.au=ALBARET,%20Guillaume&SIFRE,%20Elodie&FLOCH,%20Pauline&LAYE,%20Sophie&AUBERT,%20Agnes&rft.genre=article |
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