LEYROLLE, Quentin; DECOEUR, Fanny; DEJEAN, Cyril; BRIERE, Marie-Galadriel; LEON, Stephane; BAKOGIANNIS, Ioannis; BAROUX, Emilie; STERLEY, Tony‐Lee; BOSCH BOUJU, Clementine; MOREL, Lydie; AMADIEU, Camille; LECOURS, Cynthia; ST‐PIERRE, Marie‐Kim; BORDELEAU, Maude; DE SMEDT-PEYRUSSE, Veronique; SERE, Alexandra; SCHWENDIMANN, Leslie; GREGOIRE, Stephane; BRETILLON, Lionel; ACAR, Niyazi; JOFFRE, Corinne; FERREIRA, Guillaume; URICARU, Raluca; THEBAULT, Patricia; GRESSENS, Pierre; TREMBLAY, Marie‐Eve; LAYE, Sophie; NADJAR, Agnes

doi:10.1002/glia.24088

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LEYROLLE, Quentin
Nutrition et Neurobiologie intégrée [NutriNeuro]

DECOEUR, Fanny

Nutrition et Neurobiologie intégrée [NutriNeuro]

DEJEAN, Cyril

Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]

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Glia. 2021-09-14

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Westernization of dietary habits has led to a progressive reduction in dietary intake of n-3 polyunsaturated fatty acids (n-3 PUFAs). Low maternal intake of n-3 PUFAs has been linked to neurodevelopmental disorders, conditions in which myelination processes are abnormal, leading to defects in brain functional connectivity. Only little is known about the role of n-3 PUFAs in oligodendrocyte physiology and white matter development. Here, we show that lifelong n-3 PUFA deficiency disrupts oligodendrocytes maturation and myelination processes during the postnatal period in mice. This has long-term deleterious consequences on white matter organization and hippocampus-prefrontal functional connectivity in adults, associated with cognitive and emotional disorders. Promoting developmental myelination with clemastine, a first-generation histamine antagonist and enhancer of oligodendrocyte precursor cell differentiation, rescues memory deficits in n-3 PUFA deficient animals. Our findings identify a novel mechanism through which n-3 PUFA deficiency alters brain functions by disrupting oligodendrocyte maturation and brain myelination during the neurodevelopmental period.< Réduire

Mots clés en anglais

Clemastine

Cognition

Hippocampus

Myelin

N-3 PUFA

Neurodevelopement

Oligodendrocyte

Omega-3

Prefrontal cortex

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https://oskar-bordeaux.fr/handle/20.500.12278/112232

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http://dx.doi.org/10.1002/glia.24088

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N‐3 PUFA deficiency disrupts oligodendrocyte maturation and myelin integrity during brain development

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N‐3 PUFA deficiency disrupts oligodendrocyte maturation and myelin integrity during brain development

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