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N‐3 PUFA deficiency disrupts oligodendrocyte maturation and myelin integrity during brain development

dc.rights.licenseopenen_US
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorLEYROLLE, Quentin
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorDECOEUR, Fanny
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorDEJEAN, Cyril
hal.structure.identifierLaboratoire Bordelais de Recherche en Informatique [LaBRI]
dc.contributor.authorBRIERE, Marie-Galadriel
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorLEON, Stephane
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorBAKOGIANNIS, Ioannis
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorBAROUX, Emilie
dc.contributor.authorSTERLEY, Tony‐Lee
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorBOSCH BOUJU, Clementine
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorMOREL, Lydie
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorAMADIEU, Camille
dc.contributor.authorLECOURS, Cynthia
dc.contributor.authorST‐PIERRE, Marie‐Kim
dc.contributor.authorBORDELEAU, Maude
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorDE SMEDT-PEYRUSSE, Veronique
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorSERE, Alexandra
dc.contributor.authorSCHWENDIMANN, Leslie
dc.contributor.authorGREGOIRE, Stephane
dc.contributor.authorBRETILLON, Lionel
dc.contributor.authorACAR, Niyazi
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorJOFFRE, Corinne
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorFERREIRA, Guillaume
hal.structure.identifierLaboratoire Bordelais de Recherche en Informatique [LaBRI]
dc.contributor.authorURICARU, Raluca
hal.structure.identifierLaboratoire Bordelais de Recherche en Informatique [LaBRI]
dc.contributor.authorTHEBAULT, Patricia
dc.contributor.authorGRESSENS, Pierre
dc.contributor.authorTREMBLAY, Marie‐Eve
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorLAYE, Sophie
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorNADJAR, Agnes
dc.date.accessioned2021-09-17T10:30:03Z
dc.date.available2021-09-17T10:30:03Z
dc.date.issued2021-09-14
dc.identifier.issn0894-1491en_US
dc.identifier.urioai:crossref.org:10.1002/glia.24088
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/112232
dc.description.abstractEnWesternization of dietary habits has led to a progressive reduction in dietary intake of n-3 polyunsaturated fatty acids (n-3 PUFAs). Low maternal intake of n-3 PUFAs has been linked to neurodevelopmental disorders, conditions in which myelination processes are abnormal, leading to defects in brain functional connectivity. Only little is known about the role of n-3 PUFAs in oligodendrocyte physiology and white matter development. Here, we show that lifelong n-3 PUFA deficiency disrupts oligodendrocytes maturation and myelination processes during the postnatal period in mice. This has long-term deleterious consequences on white matter organization and hippocampus-prefrontal functional connectivity in adults, associated with cognitive and emotional disorders. Promoting developmental myelination with clemastine, a first-generation histamine antagonist and enhancer of oligodendrocyte precursor cell differentiation, rescues memory deficits in n-3 PUFA deficient animals. Our findings identify a novel mechanism through which n-3 PUFA deficiency alters brain functions by disrupting oligodendrocyte maturation and brain myelination during the neurodevelopmental period.
dc.language.isoENen_US
dc.sourcecrossref
dc.subject.enClemastine
dc.subject.enCognition
dc.subject.enHippocampus
dc.subject.enMyelin
dc.subject.enN-3 PUFA
dc.subject.enNeurodevelopement
dc.subject.enOligodendrocyte
dc.subject.enOmega-3
dc.subject.enPrefrontal cortex
dc.title.enN‐3 PUFA deficiency disrupts oligodendrocyte maturation and myelin integrity during brain development
dc.typeArticle de revueen_US
dc.identifier.doi10.1002/glia.24088en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed34519378en_US
bordeaux.journalGliaen_US
bordeaux.hal.laboratoriesNutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAEen_US
bordeaux.institutionINSERM
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.teamPsychoneuroimmunologie et Nutrition: Approches expérimentales et cliniquesen_US
bordeaux.teamNutrition, mémoire et glucocorticoïdesen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDFondation de Franceen_US
bordeaux.identifier.funderIDFondation pour la Recherche Médicaleen_US
bordeaux.identifier.funderIDInstitut National de la Recherche Agronomiqueen_US
bordeaux.identifier.funderIDInstitut National de la Santé et de la Recherche Médicaleen_US
bordeaux.import.sourcedissemin
hal.identifierhal-03347586
hal.version1
hal.date.transferred2021-09-17T10:30:09Z
hal.exporttrue
workflow.import.sourcedissemin
dc.rights.ccPas de Licence CCen_US
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