NANEIX, Fabien; GLANGETAS, Christelle; KAUFLING, Jennifer; JANTHAKHIN, Yootana; BOITARD, Chloe; DE SMEDT-PEYRUSSE, Veronique; PAPE, Jean-Remi; VANCASSEL, Sylvie; TRIFILIEFF, Pierre; GEORGES, François; COUTUREAU, Etienne; FERREIRA, Guillaume

doi:10.1523/ENEURO.0120-17.2017

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NANEIX, Fabien
Nutrition et Neurobiologie intégrée [NutriNeuro]

GLANGETAS, Christelle

Institut des Maladies Neurodégénératives [Bordeaux] [IMN]

KAUFLING, Jennifer

Langue

Article de revue

Ce document a été publié dans

eNeuro. 2017-06, vol. 4, n° 3

Résumé en anglais

Increasing evidence suggest that consumption of high-fat diet (HFD) can impact the maturation of brain circuits, such as during adolescence, which could account for behavioral alterations associated with obesity. In the present study, we used behavioral sensitization to amphetamine to investigate the effect of periadolescent HFD exposure (pHFD) in rats on the functionality of the dopamine (DA) system, a central actor in food reward processing. pHFD does not affect responding to an acute injection, however, a single exposure to amphetamine is sufficient to induce locomotor sensitization in pHFD rats. This is paralleled by rapid neurobiological adaptations within the DA system. In pHFD-exposed animals, a single amphetamine exposure induces an increase in bursting activity of DA cells in the ventral tegmental area (VTA) as well as higher DA release and greater expression of (tyrosine hydroxylase, TH) in the nucleus accumbens (NAc). Post-synaptically, pHFD animals display an increase in NAc D2 receptors and c-Fos expression after amphetamine injection. These findings highlight the vulnerability of DA system to the consumption of HFD during adolescence that may support deficits in reward-related processes observed in obesity.< Réduire

Mots clés en anglais

Adolescence

Amphetamine

Animals

Dopamine

Dopamine Agents

Dopaminergic Neurons

High-fat diet

Locomotion

Male

Nucleus Accumbens

Proto-Oncogene Proteins c-fos

Rats

sensitization

Tyrosine 3-Monooxygenase

Ventral Tegmental Area

Animals Newborn

Rats Long-Evans

Receptors Dopamine D2

URI

https://oskar-bordeaux.fr/handle/20.500.12278/112150

DOI

http://dx.doi.org/10.1523/ENEURO.0120-17.2017

Project ANR

Bases neuronales du comportement dirigé vers un but chez le Rat - ANR-14-CE13-0014
Impact neuro-cognitif de l'obésité juvénile: approches expérimentale et clinique
Programme d'investissements - Idex Bordeaux - LAPHIA

Unités de recherche

NutriNeuro (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286