| dc.rights.license | open | en_US |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | NANEIX, Fabien | |
| hal.structure.identifier | Institut des Maladies Neurodégénératives [Bordeaux] [IMN] | |
| dc.contributor.author | GLANGETAS, Christelle | |
| dc.contributor.author | KAUFLING, Jennifer | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | JANTHAKHIN, Yootana | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | BOITARD, Chloe | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | DE SMEDT-PEYRUSSE, Veronique | |
| hal.structure.identifier | Institut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA] | |
| dc.contributor.author | PAPE, Jean-Remi | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | VANCASSEL, Sylvie | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | TRIFILIEFF, Pierre | |
| dc.contributor.author | GEORGES, François | |
| hal.structure.identifier | Institut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA] | |
| dc.contributor.author | COUTUREAU, Etienne | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | FERREIRA, Guillaume | |
| dc.date.accessioned | 2021-09-08T08:14:32Z | |
| dc.date.available | 2021-09-08T08:14:32Z | |
| dc.date.issued | 2017-06 | |
| dc.identifier.issn | 2373-2822 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/112150 | |
| dc.description.abstractEn | Increasing evidence suggest that consumption of high-fat diet (HFD) can impact the maturation of brain circuits, such as during adolescence, which could account for behavioral alterations associated with obesity. In the present study, we used behavioral sensitization to amphetamine to investigate the effect of periadolescent HFD exposure (pHFD) in rats on the functionality of the dopamine (DA) system, a central actor in food reward processing. pHFD does not affect responding to an acute injection, however, a single exposure to amphetamine is sufficient to induce locomotor sensitization in pHFD rats. This is paralleled by rapid neurobiological adaptations within the DA system. In pHFD-exposed animals, a single amphetamine exposure induces an increase in bursting activity of DA cells in the ventral tegmental area (VTA) as well as higher DA release and greater expression of (tyrosine hydroxylase, TH) in the nucleus accumbens (NAc). Post-synaptically, pHFD animals display an increase in NAc D2 receptors and c-Fos expression after amphetamine injection. These findings highlight the vulnerability of DA system to the consumption of HFD during adolescence that may support deficits in reward-related processes observed in obesity. | |
| dc.description.sponsorship | Bases neuronales du comportement dirigé vers un but chez le Rat - ANR-14-CE13-0014 | en_US |
| dc.description.sponsorship | Impact neuro-cognitif de l'obésité juvénile: approches expérimentale et clinique - ANR-15-CE17-0013 | en_US |
| dc.description.sponsorship | Programme d'investissements - Idex Bordeaux - LAPHIA | en_US |
| dc.language.iso | EN | en_US |
| dc.subject.en | Adolescence | |
| dc.subject.en | Amphetamine | |
| dc.subject.en | Animals | |
| dc.subject.en | Dopamine | |
| dc.subject.en | Dopamine Agents | |
| dc.subject.en | Dopaminergic Neurons | |
| dc.subject.en | High-fat diet | |
| dc.subject.en | Locomotion | |
| dc.subject.en | Male | |
| dc.subject.en | Nucleus Accumbens | |
| dc.subject.en | Proto-Oncogene Proteins c-fos | |
| dc.subject.en | Rats | |
| dc.subject.en | sensitization | |
| dc.subject.en | Tyrosine 3-Monooxygenase | |
| dc.subject.en | Ventral Tegmental Area | |
| dc.subject.en | Animals Newborn | |
| dc.subject.en | Rats Long-Evans | |
| dc.subject.en | Receptors Dopamine D2 | |
| dc.title.en | Impact of Early Consumption of High-Fat Diet on the Mesolimbic Dopaminergic System | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1523/ENEURO.0120-17.2017 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
| dc.identifier.pubmed | 28580417 | en_US |
| bordeaux.journal | eNeuro | en_US |
| bordeaux.volume | 4 | en_US |
| bordeaux.hal.laboratories | NutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286 | en_US |
| bordeaux.issue | 3 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INRAE | en_US |
| bordeaux.team | Psychoneuroimmunologie et Nutrition: Approches expérimentales et cliniques | en_US |
| bordeaux.team | Nutrition, mémoire et glucocorticoïdes | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.identifier.funderID | Emergence de Jeune Equipe INRA | en_US |
| bordeaux.identifier.funderID | Ministère de l'Enseignement supérieur, de la Recherche et de l'Innovation | en_US |
| bordeaux.identifier.funderID | Agence Nationale de la Recherche | en_US |
| hal.export | false | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=eNeuro&rft.date=2017-06&rft.volume=4&rft.issue=3&rft.eissn=2373-2822&rft.issn=2373-2822&rft.au=NANEIX,%20Fabien&GLANGETAS,%20Christelle&KAUFLING,%20Jennifer&JANTHAKHIN,%20Yootana&BOITARD,%20Chloe&rft.genre=article | |
