BENSALEM, Julien; DUDONNE, Stephanie; ETCHAMENDY, Nicole; PELLAY, Hermine; AMADIEU, Camille; GAUDOUT, David; DUBREUIL, Severine; PARADIS, Marie-Eve; POMERLEAU, Sonia; CAPURON, Lucile; HUDON, Carol; LAYE, Sophie; DESJARDINS, Yves; PALLET, Veronique

doi:10.1093/gerona/gly166

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BENSALEM, Julien
Nutrition et Neurobiologie intégrée [NutriNeuro]

DUDONNE, Stephanie

ETCHAMENDY, Nicole

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The journals of gerontology. Series A, Biological sciences and medical sciences. 2019, vol. 74, n° 7, p. 996-1007

Résumé en anglais

Polyphenols are promising nutritional bioactives exhibiting beneficial effect on age-related cognitive decline. This study evaluated the effect of a polyphenol-rich extract from grape and blueberry (PEGB) on memory of healthy elderly subjects (60-70 years-old). A bicentric, randomized, double-blind, placebo-controlled trial was conducted with 215 volunteers receiving 600 mg/day of PEGB (containing 258 mg flavonoids) or a placebo for 6 months. The primary outcome was the CANTAB Paired Associate Learning (PAL), a visuospatial learning and episodic memory test. Secondary outcomes included verbal episodic and recognition memory (VRM) and working memory (SSP). There was no significant effect of PEGB on the PAL on the whole cohort. Yet, PEGB supplementation improved VRM-free recall. Stratifying the cohort in quartiles based on PAL at baseline revealed a subgroup with advanced cognitive decline (decliners) who responded positively to the PEGB. In this group, PEGB consumption was also associated with a better VRM-delayed recognition. In addition to a lower polyphenol consumption, the urine metabolomic profile of decliners revealed that they excreted more metabolites. Urinary concentrations of specific flavan-3-ols metabolites were associated, at the end of the intervention, with the memory improvements. Our study demonstrates that PEGB improves age-related episodic memory decline in individuals with the highest cognitive impairments.< Réduire

Mots clés en anglais

Aged

Aging

Blueberry Plants

CANTAB

Cognition

Dietary Supplements

Female

Flavan-3-ols

Flavonoids

Humans

Male

Memory

Episodic

Middle Aged

Neuropsychological Tests

PAL

Plant Extracts

Polyphenols

Presbycusis

Recognition

Psychology

Spatial Navigation

Treatment Outcome

Vitis

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https://oskar-bordeaux.fr/handle/20.500.12278/112034

DOI

http://dx.doi.org/10.1093/gerona/gly166

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Polyphenols From Grape and Blueberry Improve Episodic Memory in Healthy Elderly with Lower Level of Memory Performance: A Bicentric Double-Blind, Randomized, Placebo-Controlled Clinical Study

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Polyphenols From Grape and Blueberry Improve Episodic Memory in Healthy Elderly with Lower Level of Memory Performance: A Bicentric Double-Blind, Randomized, Placebo-Controlled Clinical Study

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Résumé en anglais

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DOI

Unités de recherche