Self-Assembly of Bilayer Vesicles Made of Saturated Long Chain Fatty Acids
Language
en
Article de revue
This item was published in
Langmuir. 2016, vol. 32, n° 2, p. 401-410
English Abstract
Saturated long chain fatty acids (sLCFA, e.g., C-14:0, C-16:0, and C-18:0) are potentially the greenest and cheapest surfactants naturally available. However, because aqueous sodium soaps of sLCFA are known to crystallize, ...Read more >
Saturated long chain fatty acids (sLCFA, e.g., C-14:0, C-16:0, and C-18:0) are potentially the greenest and cheapest surfactants naturally available. However, because aqueous sodium soaps of sLCFA are known to crystallize, the self-assembly of stable bilayer vesicles has not been reported yet. Here, by using such soaps in combination with guanidine hydrochloride (GuHCl), which has been shown recently to prevent crystallization, we were capable of producing stable bilayer vesicles made of sLCFA. The phase diagrams were established for a variety of systems showing that vesicles can form in a broad range of composition and pH. Both solid state NMR and small-angle neutron scattering allowed demonstrating that in such vesicles sLCFA are arranged in a bilayer structure which exhibits similar dynamic and structural properties as those of phospholipid membranes. We expect these vesicles to be of interest as model systems of protocells and minimal cells but also for various applications since fatty acids are potentially substitutes to phospholipids, synthetic surfactants, and polymers.Read less <