BAQUÉ, M.; LE POSTOLLEC, A.; COUSSOT, G.; MOREAU, Thibault; DESVIGNES, I.; INCERTI, S.; DOBRIJEVIC, M.; MORETTO, P.; VANDENABEELE-TRAMBOUZE, O.

doi:10.1016/j.pss.2011.06.009

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BAQUÉ, M.
Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] [IBMM]

LE POSTOLLEC, A.
sSE 2011

COUSSOT, G.
Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] [IBMM]

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Planetary and Space Science. 2011, vol. 59, n° 13, p. 1490-1497

Elsevier

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ntibody-based micro-arrays instruments are very promising tools for the search for biomarkers in planetary exploration missions. Since such instruments have never been used in this context, it is important to test their resistance to space constraints. In particular, cosmic particles might be deleterious. In the present study, we have investigated the effect of low energy protons (2 MeV) on antibody performances with fluences levels much greater than expected for a typical mission to Mars. We show that these particles do not alter significantly the antibody recognition capability for both free (in solution) and grafted (covalently bound to the support) freeze-dried antibodies. Details of the freeze-dried drying process used to optimize antibody performances during our experiments are also presented.< Réduire

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Antibody-based microarrays

Cosmic radiation

Life-detection instrument

Planetary exploration

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Biochip for astrobiological applications: Investigation of low energy protons effects on antibody performances

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