We present an atmospheric characterization study of two medium sized planets bracketing the radius of Neptune: HD 106315 c (R$_{\rm{P}}$=4.98 $\pm$ 0.23 R$_{\oplus}$) and HD 3167 c (R$_{\rm{P}}$=2.740$_{-0.100}^{+0.106}$ R$_{\oplus}$). We analyse spatially scanned spectroscopic observations obtained with the G141 grism (1.125 - 1.650 $\mu$m) of the Wide Field Camera 3 (WFC3) onboard the Hubble Space Telescope. We use the publicly available Iraclis pipeline and TauREx3 atmospheric retrieval code and we detect water vapor in the atmosphere of both planets with an abundance of $\log_{10}[\mathrm{H_2O}]=-2.1^{+0.7}_{-1.3}$ ($\sim$5.68$\sigma$) and $\log_{10}[\mathrm{H_2O}]=-4.1^{+0.9}_{-0.9}$ ($\sim$3.17$\sigma$) for HD 106315 c and HD 3167 c, respectively. The transmission spectrum of HD 106315 c shows also a possible evidence of ammonia absorption ($\log_{10}[\mathrm {NH_3}]=-4.3^{+0.7}_{-2.0}$, $\sim$1.97$\sigma$ -even if it is not significant-), whilst carbon dioxide absorption features may be present in the atmosphere of HD 3167 c in the $\sim$1.1-1.6~$\mu$m wavelength range ($\log_{10}[\mathrm{CO_{2}}]= -2.4^{+0.7}_{-1.0}$, $\sim$3.28$\sigma$). However the CO$_2$ detection appears significant, it must be considered carefully and put into perspective. Indeed, CO$_2$ presence is not explained by 1D equilibrium chemistry models, and it could be due to possible systematics. The additional contribution of clouds, CO and CH$_4$ are discussed. HD 106315 c and HD 3167 c will be interesting targets for upcoming telescopes such as the James Webb Space Telescope (JWST) and the Atmospheric Remote-Sensing Infrared Exoplanet Large-Survey (Ariel).< Réduire