NGUYEN, Phuong H.; RAMAMOORTHY, Ayyalusamy; SAHOO, Bikash R.; ZHENG, Jie; FALLER, Peter; STRAUB, John E.; DOMINGUEZ, Laura; SHEA, Joan-Emma; DOKHOLYAN, Nikolay V.; DE SIMONE, Alfonso; MA, Buyong; NUSSINOV, Ruth; NAJAFI, Saeed; NGO, Son Tung; LOQUET, Antoine; CHIRICOTTO, Mara; GANGULY, Pritam; MCCARTY, James; LI, Mai Suan; HALL, Carol; WANG, Yiming; MILLER, Yifat; MELCHIONNA, Simone; HABENSTEIN, Birgit; TIMR, Stepan; CHEN, Jiaxing; HNATH, Brianna; STRODEL, Birgit; KAYED, Rakez; LESNE, Sylvain; WEI, Guanghong; STERPONE, Fabio; DOIG, Andrew J.; DERREUMAUX, Philippe

doi:10.1021/acs.chemrev.0c01122

Métadonnées

Afficher la notice complète

Licence d’utilisation du document

NGUYEN, Phuong H.

RAMAMOORTHY, Ayyalusamy

SAHOO, Bikash R.

Langue

Article de revue

Ce document a été publié dans

Chemical Reviews. 2021, vol. 121, n° 4, p. 2545-2647

Résumé en anglais

Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting either the central nervous system or a variety of peripheral tissues. Structural and dynamic characterization of all species along the pathways from monomers to fibrils is challenging by experimental and computational means because they involve intrinsically disordered proteins in most diseases. Yet understanding how amyloid species become toxic is the challenge in developing a treatment for these diseases. Here we review what computer, in vitro, in vivo, and pharmacological experiments tell us about the accumulation and deposition of the oligomers of the (A beta, tau), alpha-synuclein, IAPP, and superoxide dismutase 1 proteins, which have been the mainstream concept underlying Alzheimer's disease (AD), Parkinson's disease (PD), type II diabetes (T2D), and amyotrophic lateral sclerosis (ALS) research, respectively, for many years.< Réduire

Mots clés en anglais

Nanofibers

Peptides and proteins

Genetics

Aggregation

Crystal cleavage

Métadonnées

Partager cette publication !

Licence d’utilisation du document

Amyloid Oligomers: A Joint Experimental/Computational Perspective on Alzheimer's Disease, Parkinson's Disease, Type II Diabetes, and Amyotrophic Lateral Sclerosis

Langue

Ce document a été publié dans

Résumé en anglais

Mots clés en anglais

URI

DOI

Unités de recherche