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Pistacia lentiscus L. leaves extract and its major phenolic compounds reverse aluminium-induced neurotoxicity in mice

dc.rights.licenseopenen_US
dc.contributor.authorAZIB, Lila
dc.contributor.authorDEBBACHE-BENAIDA, Nadjet
hal.structure.identifierUnité de Recherche Oenologie [Villenave d'Ornon] [OENO]
dc.contributor.authorDA COSTA, Gregory
dc.contributor.authorATMANI-KILANI, Dina
dc.contributor.authorSAIDENE, Naima
dc.contributor.authorAYOUNI, Karima
hal.structure.identifierUnité de Recherche Oenologie [Villenave d'Ornon] [OENO]
dc.contributor.authorRICHARD, Tristan
dc.contributor.authorATMANI, Djebbar
dc.date.accessioned2020-07-02T13:17:54Z
dc.date.available2020-07-02T13:17:54Z
dc.date.issued2019
dc.identifier.issn0926-6690en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/8474
dc.description.abstractEnPistacia lentiscus L. (Anacardeaceae), a largely distributed plant in the Mediterranean region, has long been used in human food, pharmaceutical industry and traditional medicine. P. lentiscus leaves are well known as a rich source of antioxidant polyphenols that may play a potential role in the prevention of neurodegeneration. Aluminium is a puissant neurotoxin metal; is proposed to be involved in the development of Alzheimer's disease (AD). The present study aims to examine the neuroprotective effect of P. lentiscus L. leaves extract (PL) on behavioral, histological and biochemical impairments caused by Al in male albinos mice. First, Al (100 ppm) and PL (150 and 300 ppm) were co-administered daily for two months to the mice. The extract significantly reversed all Al effects; it decreased the anxiety in head-dipping, black/ white and elevated plus maze tests, improved memory performance in Morris water maze test and inhibited histological alterations. On the other hand, in vitro study was added to determine the active principles of PL and to clarify their mode of action in the neuroprotective effect. The extract and its phenolic compounds (Myricetin rhamnoside, quercetin rhamnoside, gallic acid, myricetin and quercetin) were tested against Al-activated iron-induced lipid peroxidation in synaptosomal membrane. Results showed that PL and its bioactive compounds had a dose dependent effect where the highest effect was obtained with myricetin rhamnoside (IC50 = 0.04 mM). Therefore, PL is a source of phenolics possessing a neuroprotective potential which is validated by their ability to reverse the toxic effects caused by Al.
dc.language.isoENen_US
dc.subject.enPistacia Lentiscus L.
dc.subject.enFlavonols
dc.subject.enGallic Acid
dc.subject.enAluminium
dc.subject.enCognitive Deficit
dc.subject.enNeuroprotection
dc.title.enPistacia lentiscus L. leaves extract and its major phenolic compounds reverse aluminium-induced neurotoxicity in mice
dc.title.alternativeInd. crops prod.en_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.indcrop.2019.05.062en_US
dc.subject.halSciences du Vivant [q-bio]/Biologie végétaleen_US
bordeaux.journalIndustrial Crops and Productsen_US
bordeaux.page576-584en_US
bordeaux.volume137en_US
bordeaux.hal.laboratoriesOenologie - EA 4577en_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
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