JACQUART, Sylvaine; SIADOUS, Robin; HÉNOCQ-PIGASSE, Christel; BAREILLE, Reine; ROQUES, Christine; REY, Christian; COMBES, Christèle

doi:10.1007/s10856-013-5014-2

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JACQUART, Sylvaine
Centre interuniversitaire de recherche et d'ingénierie des matériaux [CIRIMAT]

SIADOUS, Robin
Bioingénierie tissulaire [BIOTIS]

HÉNOCQ-PIGASSE, Christel

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Journal of Materials Science: Materials in Medicine. 2013-12, vol. Vol. 24, n° n° 12, p. pp. 2665-2675

Springer Verlag

Résumé en anglais

The introduction of silver, either in the liquid phase (as silver nitrate solution: Ag(L)) or in the solid phase (as silver phosphate salt: Ag(S)) of calcium carbonate–calcium phosphate (CaCO3–CaP) bone cement, its influence on the composition of the set cement (C-Ag(L)and C-Ag(S) cements with a Ca/Ag atomic ratio equal to 10.3) and its biological properties were investigated. The fine characterisation of the chemical setting of silver-doped and reference cements was performed using FTIR spectroscopy. We showed that the formation of apatite was enhanced from the first hours of maturation of C-Ag(L) cement in comparison with the reference cement, whereas a longer period of maturation (about 10 h) was required to observe this increase for C-Ag(S) cement, although in both cases, silver was present in the set cements mainly as silver phosphate. The role of silver nitrate on the setting chemical reaction is discussed and a chemical scheme is proposed. Antibacterial activity tests (S. aureus and S. epidermidis) and in vitro cytotoxicity tests (human bone marrow stromal cells (HBMSC)) showed that silver-loaded CaCO3–CaP cements had antibacterial properties (anti-adhesion and anti-biofilm formation) without a toxic effect on HBMSC cells, making C-Ag(S) cement a promising candidate for the prevention of bone implant-associated infections.< Réduire

Mots clés en anglais

Bone cement

Silver

Physico-chemistry

Antibacterial activity

Cytotoxicity

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Composition and properties of silver-containing calcium carbonate–calcium phosphate bone cement

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