COMBE, Christian; MANN, Johannes; GOLDSMITH, David; DELLANNA, Frank; ZAOUI, Philippe; LONDON, Gérard; DENHAERYNCK, Kris; KRENDYUKOV, Andriy; ABRAHAM, Ivo; MACDONALD, Karen

doi:10.1186/s12882-019-1251-z

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COMBE, Christian
Bioingénierie tissulaire [BIOTIS]

MANN, Johannes
Friedrich-Alexander Universität Erlangen-Nürnberg = University of Erlangen-Nuremberg [FAU]

GOLDSMITH, David

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BMC Nephrology. 2019-03-05, vol. 20, n° 1, p. 81

BioMed Central

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BACKGROUND:DOPPS reported that thousands of life-years could be gained in the US and Europe over 5 years by correcting six modifiable haemodialysis practices. We estimated potential life-years gained across 10 European countries using MONITOR-CKD5 study data.METHODS:The DOPPS-based target ranges were used, except for haemoglobin due to label changes, as well as DOPPS-derived relative mortality risks. Percentages of MONITOR-CKD5 patients outside targets were calculated. Consistent with the DOPPS-based analyses, we extrapolated life-years gained for the MONITOR-CKD5 population over 5 years if all patients were within targets.RESULTS:Bringing the 10 MONITOR-CKD5 countries' dialysis populations into compliance on the six practices results in a 5-year gain of 97,428 patient-years. In descending order, survival impact was the highest for albumin levels, followed by phosphate levels, vascular access, haemoglobin, dialysis adequacy, and interdialytic weight gain.CONCLUSIONS:Optimal management of the six modifiable haemodialysis practices may achieve 6.2% increase in 5-year survival.TRIAL REGISTRATION:NCT01121237 . Clinicaltrials.gov registration May 12, 2010 (retrospectively registered).< Réduire

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Anaemia

Biosimilar epoetin alfa

Haemodialysis

Life-years

Modifiable haemodialysis practices

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Potential life-years gained over a 5-year period by correcting DOPPS-identified modifiable practices in haemodialysis: results from the European MONITOR-CKD5 study

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