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hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorOLIVEIRA, Hugo
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorCATROS, Sylvain
hal.structure.identifierInstitute for Bioengineering of Catalonia [Barcelona] [IBEC]
hal.structure.identifierBiomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine [CIBER-BBN]
hal.structure.identifierUniversitat Autònoma de Barcelona = Autonomous University of Barcelona = Universidad Autónoma de Barcelona [UAB]
dc.contributor.authorCASTANO, Oscar
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorREY, Sylvie
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorSIADOUS, Robin
hal.structure.identifierInstitute for Bioengineering of Catalonia [Barcelona] [IBEC]
hal.structure.identifierBiomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine [CIBER-BBN]
dc.contributor.authorCLIFT, Douglas
hal.structure.identifierInstitute for Bioengineering of Catalonia [Barcelona] [IBEC]
hal.structure.identifierBiomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine [CIBER-BBN]
dc.contributor.authorMARTI-MUNOZ, Joan
hal.structure.identifierInstitute for Bioengineering of Catalonia [Barcelona] [IBEC]
hal.structure.identifierBiomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine [CIBER-BBN]
dc.contributor.authorBATISTA, Marc
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorBAREILLE, Reine
hal.structure.identifierInstitute for Bioengineering of Catalonia [Barcelona] [IBEC]
hal.structure.identifierBiomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine [CIBER-BBN]
hal.structure.identifierUniversitat Autònoma de Barcelona = Autonomous University of Barcelona = Universidad Autónoma de Barcelona [UAB]
dc.contributor.authorPLANELL, Josep
hal.structure.identifierInstitute for Bioengineering of Catalonia [Barcelona] [IBEC]
hal.structure.identifierBiomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine [CIBER-BBN]
hal.structure.identifierUniversitat Politècnica de Catalunya = Université polytechnique de Catalogne [Barcelona] [UPC]
dc.contributor.authorENGEL, Elisabeth
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorAMÉDÉE, Joëlle
dc.date.accessioned2021-06-10T07:03:56Z
dc.date.available2021-06-10T07:03:56Z
dc.date.issued2017-05
dc.identifier.issn1742-7061
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/78943
dc.description.abstractEnInsufficient angiogenesis remains a major hurdle in current bone tissue engineering strategies. An extensive body of work has focused on the use of angiogenic factors or endothelial progenitor cells. However, these approaches are inherently complex, in terms of regulatory and methodologic implementation, and present a high cost. We have recently demonstrate the potential of electrospun poly(lactic acid) (PLA) fiber-based membranes, containing calcium phosphate (CaP) ormoglass particles, to elicit angiogenesis in vivo, in a subcutaneous model in mice. Here we have devised an injectable composite, containing CaP glass-ceramic particles, dispersed within a (Hydroxypropyl)methyl cellulose (HPMC) matrix, with the capacity to release calcium in a more sustained fashion. We show that by tuning the release of calcium in vivo, in a rat bone defect model, we could improve both bone formation and increase angiogenesis. The bone regeneration kinetics was dependent on the Ca2+ release rate, with the faster Ca2+ release composite gel showing improved bone repair at 3weeks, in relation to control. In the same line, improved angiogenesis could be observed for the same gel formulation at 6weeks post implantation. This methodology allows to integrate two fundamental processes for bone tissue regeneration while using a simple, cost effective, and safe approach.Statement of significance: In current bone tissue engineering approaches the achievement of sufficient angiogenesis, during tissue regeneration, is a major limitation in order to attain full tissue functionality. Recently, we have shown that calcium ions, released by the degradation of calcium phosphate ormoglasses (CaP), are effective angiogenic promoters, in both in vitro and in a subcutaneous implantation model. Here, we devised an injectable composite, containing CaP glass-ceramic particles, dispersed within a HPMC matrix, enabling the release of calcium in a more sustained fashion. We show that by tuning the release of calcium in vivo, in a rat bone defect model, we could improve both bone formation and increase angiogenesis. This simple and cost effective approach holds great promise to translate to the clinics.
dc.language.isoen
dc.publisherElsevier
dc.subject.enAngiogenesis
dc.subject.enBone regeneration
dc.subject.enCalcium phosphate ormoglasses
dc.title.enThe proangiogenic potential of a novel calcium releasing composite biomaterial: Orthotopic in vivo evaluation
dc.typeArticle de revue
dc.identifier.doi10.1016/j.actbio.2017.02.039
dc.subject.halSciences du Vivant [q-bio]
bordeaux.journalActa Biomaterialia
bordeaux.page377-385
bordeaux.volume54
bordeaux.hal.laboratoriesBioingénierie Tissulaire (BioTis) - U1026*
bordeaux.institutionCNRS
bordeaux.institutionINSERM
bordeaux.institutionCHU de Bordeaux
bordeaux.institutionInstitut Bergonié
bordeaux.peerReviewedoui
hal.identifierinserm-02870936
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//inserm-02870936v1
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