ENAUD, Raphael; HOOKS, Katarzyna B; BARRE, Aurelien; BARNETCHE, T.; HUBERT, Christophe; MASSOT, Marie; BAZIN, T.; CLOUZEAU, H.; BUI, S.; FAYON, Michael; BERGER, Patrick; LEHOURS, Philippe; BEBEAR, Cecile; NIKOLSKI, Macha; LAMIREAU, Thierry; DELHAES, Laurence; SCHAEVERBEKE, Thierry

doi:10.3390/jcm8050645

Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]

HOOKS, Katarzyna B
Laboratoire Bordelais de Recherche en Informatique [LaBRI]

BARRE, Aurelien
Laboratoire Bordelais de Recherche en Informatique [LaBRI]

Langue

Article de revue

Ce document a été publié dans

J Clin Med. 2019-05-10, vol. 8, n° 5

Résumé en anglais

Cystic fibrosis (CF) is a systemic genetic disease that leads to pulmonary and digestive disorders. In the majority of CF patients, the intestine is the site of chronic inflammation and microbiota disturbances. The link between gut inflammation and microbiota dysbiosis is still poorly understood. The main objective of this study was to assess gut microbiota composition in CF children depending on their intestinal inflammation. We collected fecal samples from 20 children with CF. Fecal calprotectin levels were measured and fecal microbiota was analyzed by 16S rRNA sequencing. We observed intestinal inflammation was associated with microbiota disturbances characterized mainly by increased abundances of Staphylococcus, Streptococcus, and Veillonella dispar, along with decreased abundances of Bacteroides, Bifidobacterium adolescentis, and Faecalibacterium prausnitzii. Those changes exhibited similarities with that of Crohn's disease (CD), as evidenced by the elevated CD Microbial-Dysbiosis index that we applied for the first time in CF. Furthermore, the significant over-representation of Streptococcus in children with intestinal inflammation appears to be specific to CF and raises the issue of gut-lung axis involvement. Taken together, our results provide new arguments to link gut microbiota and intestinal inflammation in CF and suggest the key role of the gut-lung axis in the CF evolution.< Réduire

Mots clés en anglais

LEHA

URI

https://oskar-bordeaux.fr/handle/20.500.12278/7805

DOI

http://dx.doi.org/10.3390/jcm8050645

Unités de recherche

Bordeaux Population Health Research Center (BPH) - UMR 1219

Voir/Ouvrir

Métadonnées

Partager cette publication !

Licence d’utilisation du document

Intestinal Inflammation in Children with Cystic Fibrosis Is Associated with Crohn's-Like Microbiota Disturbances

Langue

Ce document a été publié dans

Résumé en anglais

Mots clés en anglais

URI

DOI

Unités de recherche