PU, Yubing; LARATTE, Bertrand; MARKS, Robert; IONESCU, Rodica Elena

doi:10.1016/j.mtcomm.2017.02.008

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PU, Yubing
Laboratoire de Nanotechnologie et d'Instrumentation Optique [LNIO]
Centre de Recherches et d'Etudes Interdisciplinaires sur le Développement Durable [CREIDD]

LARATTE, Bertrand

Centre de Recherches et d'Etudes Interdisciplinaires sur le Développement Durable [CREIDD]

MARKS, Robert
Ben-Gurion University of the Negev [BGU]

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Materials Today Communications. 2017, vol. 11, p. 68-75

Elsevier

Résumé en anglais

There is a need by the European Commission (EC) regulations, as well as others, to reduce the in vivo toxicity tests made on animals. Conventional in vitro tests were designed for non-nanoparticle sized entities, and therefore do not necessarily assess the adverse impacts of engineered nanoparticles (ENPs) on humans. Life cycle assessment (LCA) is a widely used methodology for evaluating the environmental performance of products. Nevertheless, the application of LCA on ENPs is difficult because the characterization factors (CFs) of ENPs, as significant input parameters in LCA, remain a major unknown. It is a premise of this study to monitor the chemiluminescence (CL) spectra resulting from the reactive oxygen species (ROS) trigger made from the presence of copper nanoparticles (CuNPs) to porcine neutrophils in vitro, thereby enabling to calculate the porcine and human toxicity CFs. The framework of a scientific consensus model, USEtox model, is selected and the midpoint of CF is set as the inflammation of pig or human. Finally, the present study recommends human and porcine inflammation CFs of CuNPs in Europe to be 1.07 and 2.90 CTU (comparative toxic units) respectively.< Réduire

Mots clés en anglais

Copper nanoparticles

USEtox model

Characterization factor

Porcine neutrophils

in vitro chemiluminescence

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Impact of copper nanoparticles on porcine neutrophils: Proposition of an ultrasensitive characterization factor using chemiluminescence information and USEtox assessment model

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