BUSIGNIES, Virginie; SIMON, Grégory; MOLLEREAU, G.; BOURRY, O.; MAZEL, Vincent; ROSA-CALATRAVA, Manuel; TCHORELOFF, Pierre

doi:10.1016/j.ijpharm.2018.01.021

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BUSIGNIES, Virginie

SIMON, Grégory
Laboratoire de Ploufragan - Plouzané
Université Bretagne Loire [UBL]

MOLLEREAU, G.

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International Journal of Pharmaceutics. 2018-03, vol. 538, n° 1-2, p. 87-96

Elsevier

Résumé en anglais

Liquid vaccine formulations present some disadvantages such as stability problems, cold chain requirement or administration by trained personnel. Vaccine formulated as tablets would present a wide range of progress such as an increase stability that would facilitate the administration, the distribution and the storage of vaccine formulations. This work investigates the possibility to develop a mucosal tablet vaccine for human influenza viruses. The tablets were tested in vitro for biological efficacy and stability and in vivo in swine as a model for influenza A virus immunity. First, the ability to produce by compaction a stable vaccine with a preserved antigen was demonstrated. In a second part, vaccine tablets were used to immunize pigs. After positioning the tablets on the buccal mucosa, the animals were challenged by inoculation of the A/H1N1 pandemic virus. The responses were compared to those observed in animals vaccinated intramuscularly with the commercial liquid vaccine. It was observed signs of priming of the pig's immune system with vaccine tablets, even if the immune response stayed lower than vaccination by intramuscular route. Thus, we present attractive results that indicate a promising potential for mucosal vaccine tablets.< Réduire

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Pig

Pre-clinical evaluation

Orthomyxoviridae Infections

Mucosal vaccination

Animals

Female

Influenza A Virus

H1N1 Subtype

Influenza Vaccines

Influenza virus

Injections

Intramuscular

Male

Mouth Mucosa

Swine

Tablets

Vaccination

Vaccine tablet

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Development and pre-clinical evaluation in the swine model of a mucosal vaccine tablet for human influenza viruses: A proof-of-concept study

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