Chemical Master Equation Empirical Moment Closure
Idioma
en
Article de revue
Este ítem está publicado en
Biological Systems: Open Access. 2016, vol. 5, n° 1, p. 1-12
Omics Publishing Group
Resumen en inglés
The numerical solution of the Chemical Master Equation (CME) governing gene regulatory networks and cell signaling processes remains a challenging task due to its complexity, exponentially growing with the number of species ...Leer más >
The numerical solution of the Chemical Master Equation (CME) governing gene regulatory networks and cell signaling processes remains a challenging task due to its complexity, exponentially growing with the number of species involved. When considering separated representations of the probability distribution function within the Proper Generalized Decomposition-PGD-frame-work the complexity of the CME grows only linearly with the number of state space dimensions. In order to speed up calculations moment-based descriptions are usually preferred, however these descriptions involve the necessity of using closure relations whose impact on the calculated solution is most of time unpredictable. In this work we propose an empirical closure, fitted from the solution of the chemical master equation, the last solved within the PGD framework.< Leer menos
Palabras clave en inglés
Closure relations
Curse of dimensionality
Proper generalized decomposition
Chemical master equation
Orígen
Importado de HalCentros de investigación