JIANG, Jian-Qiao; CHANSEAU, Christel; ALVES, Isabel; NLATE, Sylvain; DURRIEU, Marie-Christine

doi:10.1016/j.isci.2019.10.014

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JIANG, Jian-Qiao
Chimie et Biologie des Membranes et des Nanoobjets [CBMN]

CHANSEAU, Christel
Chimie et Biologie des Membranes et des Nanoobjets [CBMN]

ALVES, Isabel

Chimie et Biologie des Membranes et des Nanoobjets [CBMN]

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iScience. 2019, vol. 21, p. 110-123

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Microvesicles (MVs) are used by various types of cells in the human body for intercellular communication, making them biomarkers of great potential for the early and non-evasive diagnosis of a spectrum of diseases. An integrated analysis including morphological, quantitative, and compositional studies is most desirable for the clinical application of MV detection; however, such integration is limited by the currently available analysis techniques. In this context, exploiting the phosphatidylserine (PS) exposure of MVs, we synthesized a series of dendritic molecules with PS-binding sites at the periphery. PS-dendron binding was studied at the molecular level using NMR approaches, whereas PS-containing membrane-dendron interaction was investigated in an aqueous environment using plasmon waveguide resonance spectroscopy. As a proof of concept, polyethylene terephthalate surface was functionalized with the synthetic dendrons, forming devices that can capture MVs to facilitate their subsequent analyses.< Leer menos

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Chemistry

Supramolecular Chemistry

Surface Science

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Dendron-Functionalized Surface: Efficient Strategy for Enhancing the Capture of Microvesicles

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