DESBOIS, Léo; TCHORELOFF, Pierre; MAZEL, Vincent

doi:10.1016/j.ijpharm.2020.119695

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DESBOIS, Léo
Institut de Mécanique et d'Ingénierie [I2M]

TCHORELOFF, Pierre

Institut de Mécanique et d'Ingénierie [I2M]

MAZEL, Vincent

Université de Bordeaux [UB]
Institut de Mécanique et d'Ingénierie [I2M]

Langue

Article de revue

Ce document a été publié dans

International Journal of Pharmaceutics. 2020-09, vol. 587, p. 1-7

Elsevier

Résumé en anglais

Evolution of the compaction properties of powders with the compaction speed (strain rate sensitivity, SRS) is a common phenomenon during the manufacturing of pharmaceutical tablets. Nevertheless, several different phenomena can be responsible of the SRS like friction, viscoelasticity, viscoplasticity or air entrapment.In this work, an original experimental methodology was developed to characterize specifically the viscoelasticity of tablets using a compaction simulator. After various compressions, tablets were finally loaded elastically at different constant strain rates. This methodology made it possible to measure the apparent bulk and shear moduli as a function of the strain rate. The methodology was successfully applied to microcrystalline cellulose (MCC), Starch, Lactose monohydrate (GLac) and Anhydrous Calcium Phosphate (ACP). No significant evolution of the moduli was found for Lac and ACP as expected. On the contrary, for MCC and Starch, both shear and bulk moduli were found to increase along with the strain rate. The viscoelastic behavior was then successfully modeled using prony series. Assessment of the model parameters was achieved by inverse identification using an analytical model and a finite element analysis.< Réduire

Mots clés en anglais

Viscoelasticity

Compaction

Speed

Strain rate sensitivity

Mechanical behavior

Tablet

URI

https://oskar-bordeaux.fr/handle/20.500.12278/75823

DOI

http://dx.doi.org/10.1016/j.ijpharm.2020.119695

Project ANR

Clivage en compression pharmaceutique - ANR-17-CE08-0015

Origine

Importé de hal

Unités de recherche

Institut de Mécanique et d’Ingénierie de Bordeaux (I2M) - UMR 5295