MAZEL, Vincent; TCHORELOFF, Pierre

doi:10.1016/j.xphs.2020.07.021

Métadonnées

Afficher la notice complète

Licence d’utilisation du document

MAZEL, Vincent

Institut de Mécanique et d'Ingénierie [I2M]

TCHORELOFF, Pierre

Institut de Mécanique et d'Ingénierie [I2M]

Langue

Article de revue

Ce document a été publié dans

Journal of Pharmaceutical Sciences. 2020-10, vol. 109, n° 10, p. 3210-3213

Wiley

Résumé en anglais

Capping is an important industrial problem that can arise during the manufacturing of pharmaceutical tablets. It corresponds, for biconvex tablets, to the detachment of one of the cups of the tablet during the ejection from the press or after relaxation. Solutions to this problem remain mainly empirical. Among them, precompression is widely used. One of the most popular explanation of the role of precompression in the mitigation of capping is that it increases the total time under compression. Following this interpretation, press manufacturers developped devices or machines that make it possible to maintain the pressure between precompression and main compression. In this note, we present a case study of capping. For the formulation proposed, a precompression that was maintained until the compression gave similar results as no precompression at all, i.e. capping of all the tablets. On the contrary, if the precompression was released before compression, capping stops completely. In this case, the effect of precompression is thus due to the separation of two compression events. Moreover, results prove that this separation must last long enough for the precompression to be efficient. This example shows that effect of precompression is more complex than often described in the literature.< Réduire

Mots clés en anglais

Tableting

Capping

Precompression

Tablet

Métadonnées

Partager cette publication !

Licence d’utilisation du document

Role of precompression in the mitigation of capping: a case study

Langue

Ce document a été publié dans

Résumé en anglais

Mots clés en anglais

URI

DOI

Origine

Unités de recherche