BONHOMMEAU, Sebastien; LECOMTE, Sophie

doi:10.1002/cphc.201701067

Metadatos

Mostrar el registro completo del ítem

Licencia de uso del documento

BONHOMMEAU, Sebastien

Institut des Sciences Moléculaires [ISM]

LECOMTE, Sophie
Chimie et Biologie des Membranes et des Nanoobjets [CBMN]

Idioma

Article de revue

Este ítem está publicado en

Chemphyschem. 2018, vol. 19, n° 1, p. 8-18

Resumen en inglés

Due to its high molecular sensitivity and spatial optical resolution down to sub-nanometer values, tip-enhanced Raman spectroscopy (TERS) has emerged as a powerful microscopy technique for nanoscale characterization. Progress in TERS instrumentation and in the manufacturing of efficient TERS tips allow for chemical and structural analysis under various experimental conditions (different wavelengths, substrates, and surrounding media). Many biological species have been examined by using this technique. Nucleic acids (individual nucleobases, DNA, and RNA) can show specific TERS features that reveal their composition, conformation, and defects. TERS studies on peptides and proteins (such as amyloid fibrils) provide relevant information on their morphology and structure, leading to valuable insight to their functions and behavior. Finally, lipid layers and membranes, viruses, bacteria, and cells can also be finely characterized. Generalizing TERS measurements in liq- uid medium to study biological systems is the main future challenge.< Leer menos

Palabras clave en inglés

biomolecules

proteins

Raman spectroscopy

tip-enhanced Raman spectroscopy (TERS)

structure elucidation

Metadatos

Compartir este ítem

Licencia de uso del documento

Tip-Enhanced Raman Spectroscopy: A Tool for Nanoscale Chemical and Structural Characterization of Biomolecules

Idioma

Este ítem está publicado en

Resumen en inglés

Palabras clave en inglés

URI

DOI

Centros de investigación