GRASSET, Leslie; SMIT, R. A. J.; CAUNCA, M. R.; ELFASSY, T.; ODDEN, M. C.; VAN DER GROND, J.; VAN BUCHEM, M. A.; STOTT, D. J.; SATTAR, N.; TROMPET, S.; JUKEMA, J. W.; ZEKI AL HAZZOURI, A.

doi:10.1177/0898264320916959

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GRASSET, Leslie
Bordeaux population health [BPH]

SMIT, R. A. J.

CAUNCA, M. R.

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Journal of Aging and Health. 2020-10, vol. 32, n° 9, p. 1267-1274

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Objective: We aimed to examine whether variability in high-density lipoprotein cholesterol (HDL-c) over time was associated with cognitive function. Method: We conducted a post hoc analysis of the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER) trial. Our sample included 4,428 participants with at least two repeated HDL-c measures between Months 3 and 24 postbaseline and with cognitive assessments at Month 30. HDL-c variability was defined as the intraindividual standard deviation over each person's repeated measurements. Results: Higher HDL-c variability was associated with worse performance on the Letter-Digit Coding Test (β [95% confidence interval] [CI] = -4.39 [-7.36, -1.43], p = .004), immediate recall on the 15-Picture Learning Test (β [95% CI] = -0.98 [-1.86, -0.11], p = .027), and delayed recall on the 15-Picture Learning Test (β [95% CI] = -1.90 [-3.14, -0.67], p = .002). The associations did not vary by treatment group. Discussion: Our findings suggest that variability in HDL-c may be associated with poor cognitive function among older adults.< Réduire

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Association of High-Density Lipoprotein Cholesterol With Cognitive Function: Findings From the PROspective Study of Pravastatin in the Elderly at Risk

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