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Association of High-Density Lipoprotein Cholesterol With Cognitive Function: Findings From the PROspective Study of Pravastatin in the Elderly at Risk

dc.rights.licenseopenen_US
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorGRASSET, Leslie
dc.contributor.authorSMIT, R. A. J.
dc.contributor.authorCAUNCA, M. R.
dc.contributor.authorELFASSY, T.
dc.contributor.authorODDEN, M. C.
dc.contributor.authorVAN DER GROND, J.
dc.contributor.authorVAN BUCHEM, M. A.
dc.contributor.authorSTOTT, D. J.
dc.contributor.authorSATTAR, N.
dc.contributor.authorTROMPET, S.
dc.contributor.authorJUKEMA, J. W.
dc.contributor.authorZEKI AL HAZZOURI, A.
dc.date.accessioned2021-03-23T09:13:58Z
dc.date.available2021-03-23T09:13:58Z
dc.date.issued2020-10
dc.identifier.issn1552-6887 (Electronic) 0898-2643 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/26784
dc.description.abstractEnObjective: We aimed to examine whether variability in high-density lipoprotein cholesterol (HDL-c) over time was associated with cognitive function. Method: We conducted a post hoc analysis of the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER) trial. Our sample included 4,428 participants with at least two repeated HDL-c measures between Months 3 and 24 postbaseline and with cognitive assessments at Month 30. HDL-c variability was defined as the intraindividual standard deviation over each person's repeated measurements. Results: Higher HDL-c variability was associated with worse performance on the Letter-Digit Coding Test (β [95% confidence interval] [CI] = -4.39 [-7.36, -1.43], p = .004), immediate recall on the 15-Picture Learning Test (β [95% CI] = -0.98 [-1.86, -0.11], p = .027), and delayed recall on the 15-Picture Learning Test (β [95% CI] = -1.90 [-3.14, -0.67], p = .002). The associations did not vary by treatment group. Discussion: Our findings suggest that variability in HDL-c may be associated with poor cognitive function among older adults.
dc.language.isoENen_US
dc.title.enAssociation of High-Density Lipoprotein Cholesterol With Cognitive Function: Findings From the PROspective Study of Pravastatin in the Elderly at Risk
dc.title.alternativeJ Aging Healthen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1177/0898264320916959en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed32456512en_US
bordeaux.journalJournal of Aging and Healthen_US
bordeaux.page1267-1274en_US
bordeaux.volume32en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue9en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamVINTAGEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03177372
hal.version1
hal.date.transferred2021-03-23T09:14:01Z
hal.exporttrue
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