BLIN, Patrick; ROUYER, Magali; GUIARD, Estelle; ZERBIB, F.; DIQUET, B.; MEGRAUD, F.; TISON, F.; ABOUELFATH, Abdelilah; LASSALLE, R.; DROZ-PERROTEAU, Cecile; MOORE, Nicholas

doi:10.1016/j.therap.2020.09.002

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BLIN, Patrick
Bordeaux population health [BPH]

ROUYER, Magali

Bordeaux population health [BPH]

GUIARD, Estelle
Bordeaux population health [BPH]

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Thérapie. 2021-09, vol. 76, n° 5, p. 435-440

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BACKGROUND: Quadruple therapy using a single capsule formulation of bismuth, metronidazole and tetracycline (BMT; Pylera®), associated with omeprazole for the eradication of Helicobacter pylori, represents the reintroduction of bismuth in France after 40 years. OBJECTIVE: To describe the real-life patterns of use of BMT following a request from the French health authorities. METHODS: Patients with a first BMT dispensing (index date, ID), with one year of data before and after ID, were identified in the French nationwide claims database 1/97 sample. Misuse of BMT was defined as dispensing>1 pack of BMT at ID or absence of a diagnostic test in the preceding year. RESULTS: In total, 540 patients were included. Prescribers were gastroenterologists (n=243; 45%) and general practitioners (n=160; 30%). A proton pump inhibitor was co-dispensed to 504 patients (96%). Ten patients (2%) had contraindications to BMT. Fifty-nine patients (11%) met the misuse criteria: ten (2%) were dispensed>1 pack of BMT and 49 (9%) had not had a diagnostic test for H. pylori in the previous year. During follow-up, 27 patients (5%) required retreatment (treatment failure). CONCLUSION: In this real-life study, most patients were dispensed only one pack of BMT, consistent with recommendations. Misuse related principally to the absence of prior diagnostic test for H. pylori.< Réduire

Mots clés en anglais

Helicobacter pylori

Bismuth

Metronidazole

Tetracycline

France

Misuse

Pharmacoepidemiology

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Patterns of quadruple therapy use including bismuth for Helicobacter pylori eradication: A cohort study in the French national claims database

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