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Patterns of quadruple therapy use including bismuth for Helicobacter pylori eradication: A cohort study in the French national claims database

dc.rights.licenseopenen_US
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBLIN, Patrick
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorROUYER, Magali
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorGUIARD, Estelle
dc.contributor.authorZERBIB, F.
dc.contributor.authorDIQUET, B.
dc.contributor.authorMEGRAUD, F.
dc.contributor.authorTISON, F.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorABOUELFATH, Abdelilah
dc.contributor.authorLASSALLE, R.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDROZ-PERROTEAU, Cecile
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMOORE, Nicholas
dc.date.accessioned2021-03-22T14:10:11Z
dc.date.available2021-03-22T14:10:11Z
dc.date.issued2021-09
dc.identifier.issn1958-5578 (Electronic) 0040-5957 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/26774
dc.description.abstractEnBACKGROUND: Quadruple therapy using a single capsule formulation of bismuth, metronidazole and tetracycline (BMT; Pylera®), associated with omeprazole for the eradication of Helicobacter pylori, represents the reintroduction of bismuth in France after 40 years. OBJECTIVE: To describe the real-life patterns of use of BMT following a request from the French health authorities. METHODS: Patients with a first BMT dispensing (index date, ID), with one year of data before and after ID, were identified in the French nationwide claims database 1/97 sample. Misuse of BMT was defined as dispensing>1 pack of BMT at ID or absence of a diagnostic test in the preceding year. RESULTS: In total, 540 patients were included. Prescribers were gastroenterologists (n=243; 45%) and general practitioners (n=160; 30%). A proton pump inhibitor was co-dispensed to 504 patients (96%). Ten patients (2%) had contraindications to BMT. Fifty-nine patients (11%) met the misuse criteria: ten (2%) were dispensed>1 pack of BMT and 49 (9%) had not had a diagnostic test for H. pylori in the previous year. During follow-up, 27 patients (5%) required retreatment (treatment failure). CONCLUSION: In this real-life study, most patients were dispensed only one pack of BMT, consistent with recommendations. Misuse related principally to the absence of prior diagnostic test for H. pylori.
dc.language.isoENen_US
dc.subject.enHelicobacter pylori
dc.subject.enBismuth
dc.subject.enMetronidazole
dc.subject.enTetracycline
dc.subject.enFrance
dc.subject.enMisuse
dc.subject.enPharmacoepidemiology
dc.title.enPatterns of quadruple therapy use including bismuth for Helicobacter pylori eradication: A cohort study in the French national claims database
dc.title.alternativeTherapieen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.therap.2020.09.002en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed33334580en_US
bordeaux.journalThérapieen_US
bordeaux.page435-440
bordeaux.volume76
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.issue5
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamPharmacoEpi-Drugsen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03176588
hal.version1
hal.date.transferred2021-03-22T14:10:16Z
hal.exporttrue
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