PLANCHE, V.; BOUTELOUP, Vincent; MANGIN, J. F.; DUBOIS, B.; DELRIEU, J.; PASQUIER, F.; BLANC, F.; PAQUET, C.; HANON, O.; GABELLE, A.; CECCALDI, M.; ANNWEILER, C.; KROLAK-SALMON, P.; HABERT, M. O.; FISCHER, C.; CHUPIN, M.; BEJOT, Y.; GODEFROY, O.; WALLON, D.; SAUVEE, M.; BOURDEL-MARCHASSON, Isabelle; JALENQUES, I.; TISON, F.; CHENE, Genevieve; DUFOUIL, Carole

doi:10.1002/alz.12231

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PLANCHE, V.

BOUTELOUP, Vincent
Bordeaux population health [BPH]

MANGIN, J. F.

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Alzheimer's and Dementia. 2020-12-15

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INTRODUCTION: The clinical relevance of brain atrophy subtypes categorization in non-demented persons without a priori knowledge regarding their amyloid status or clinical presentation is unknown. METHODS: A total of 2083 outpatients with either subjective cognitive complaint or mild cognitive impairment at study entry were followed during 4 years (MEMENTO cohort). Atrophy subtypes were defined using baseline magnetic resonance imaging (MRI) and previously described algorithms. RESULTS: Typical/diffuse atrophy was associated with faster cognitive decline and the highest risk of developing dementia and Alzheimer's disease (AD) over time, both in the whole analytic sample and in amyloid-positive participants. Hippocampal-sparing and limbic-predominant atrophy were also associated with incident dementia, with faster cognitive decline in the limbic predominant atrophy group. Lewy body dementia was more frequent in the hippocampal-sparing and minimal/no atrophy groups. DISCUSSION: Atrophy subtypes categorization predicted different subsequent patterns of cognitive decline and rates of conversion to distinct etiologies of dementia in persons attending memory clinics.< Réduire

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Clinical relevance of brain atrophy subtypes categorization in memory clinics

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