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Clinical relevance of brain atrophy subtypes categorization in memory clinics

dc.rights.licenseopenen_US
dc.contributor.authorPLANCHE, V.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBOUTELOUP, Vincent
dc.contributor.authorMANGIN, J. F.
dc.contributor.authorDUBOIS, B.
dc.contributor.authorDELRIEU, J.
dc.contributor.authorPASQUIER, F.
dc.contributor.authorBLANC, F.
dc.contributor.authorPAQUET, C.
dc.contributor.authorHANON, O.
dc.contributor.authorGABELLE, A.
dc.contributor.authorCECCALDI, M.
dc.contributor.authorANNWEILER, C.
dc.contributor.authorKROLAK-SALMON, P.
dc.contributor.authorHABERT, M. O.
dc.contributor.authorFISCHER, C.
dc.contributor.authorCHUPIN, M.
dc.contributor.authorBEJOT, Y.
dc.contributor.authorGODEFROY, O.
dc.contributor.authorWALLON, D.
dc.contributor.authorSAUVEE, M.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBOURDEL-MARCHASSON, Isabelle
dc.contributor.authorJALENQUES, I.
dc.contributor.authorTISON, F.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorCHENE, Genevieve
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDUFOUIL, Carole
dc.date.accessioned2021-03-16T14:51:58Z
dc.date.available2021-03-16T14:51:58Z
dc.date.issued2020-12-15
dc.identifier.issn1552-5260en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/26696
dc.description.abstractEnINTRODUCTION: The clinical relevance of brain atrophy subtypes categorization in non-demented persons without a priori knowledge regarding their amyloid status or clinical presentation is unknown. METHODS: A total of 2083 outpatients with either subjective cognitive complaint or mild cognitive impairment at study entry were followed during 4 years (MEMENTO cohort). Atrophy subtypes were defined using baseline magnetic resonance imaging (MRI) and previously described algorithms. RESULTS: Typical/diffuse atrophy was associated with faster cognitive decline and the highest risk of developing dementia and Alzheimer's disease (AD) over time, both in the whole analytic sample and in amyloid-positive participants. Hippocampal-sparing and limbic-predominant atrophy were also associated with incident dementia, with faster cognitive decline in the limbic predominant atrophy group. Lewy body dementia was more frequent in the hippocampal-sparing and minimal/no atrophy groups. DISCUSSION: Atrophy subtypes categorization predicted different subsequent patterns of cognitive decline and rates of conversion to distinct etiologies of dementia in persons attending memory clinics.
dc.language.isoENen_US
dc.title.enClinical relevance of brain atrophy subtypes categorization in memory clinics
dc.title.alternativeAlzheimers Dementen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1002/alz.12231en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed33325121en_US
bordeaux.journalAlzheimer's and Dementiaen_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamUSMRen_US
bordeaux.teamVINTAGEen_US
bordeaux.teamMORPH3Eusen_US
bordeaux.teamMEMENTOen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03170988
hal.version1
hal.date.transferred2021-03-16T14:52:03Z
hal.exporttrue
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