PLCG2 protective variant p.P522R modulates tau pathology and disease progression in patients with mild cognitive impairment
Language
EN
Article de revue
This item was published in
Acta Neuropathologica. 2020, vol. 139, n° 6, p. 1025-1044
English Abstract
pinnings, we identified a network of co-expressed proteins connecting PLCG2 to APOE and TREM2 using unsupervised co-regulatory network analysis. The network was highly enriched for the complement cascade and genes ...Read more >
pinnings, we identified a network of co-expressed proteins connecting PLCG2 to APOE and TREM2 using unsupervised co-regulatory network analysis. The network was highly enriched for the complement cascade and genes differentially expressed in disease-associated microglia. Our data show that p.P522R in PLCG2 reduces AD disease progression by mitigating tau pathology in the presence of amyloid pathology and, as a consequence, maintains cognitive function. Targeting the enzyme PLCG2 might provide a new therapeutic approach for treating AD.Read less <
Keywords
SEPIA
HEALTHY