SANTOS, M. E.; PROTOPOPESCU, C.; SOGNI, P.; YAYA, I.; PIROTH, L.; BAILLY, F.; MARCELLIN, F.; ESTERLE, Laure; WITTKOP, Linda; ROSENTHAL, E.; MORLAT, Philippe; ROUX, P.; DE ARAUJO, W. N.; SALMON-CERON, D.; CARRIERI, M. P.

doi:10.1007/s10461-019-02585-7

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AIDS and Behavior. 2020, vol. 24, n° 4, p. 1069-1084

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Mortality among individuals co-infected with HIV and hepatitis C virus (HCV) is relatively high. We evaluated the association between psychoactive substance use and both HCV and non-HCV mortality in HIV/HCV co-infected patients in France, using Fine and Gray’s competing-risk model adjusted for socio-demographic, clinical predictors and confounding factors, while accounting for competing causes of death. Over a 5-year median follow-up period, 77 deaths occurred among 1028 patients. Regular/daily cannabis use, elevated coffee intake, and not currently smoking were independently associated with reduced HCV-mortality (adjusted sub-hazard ratio [95% CI] 0.28 [0.10–0.83], 0.38 [0.15–0.95], and 0.28 [0.10–0.79], respectively). Obesity and severe thinness were associated with increased HCV-mortality (2.44 [1.00–5.93] and 7.25 [2.22–23.6] versus normal weight, respectively). Regular binge drinking was associated with increased non-HCV-mortality (2.19 [1.10–4.37]). Further research is needed to understand the causal mechanisms involved. People living with HIV/HCV co-infection should be referred for tobacco, alcohol and weight control interventions and potential benefits of cannabis-based therapies investigated.< Réduire

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HCV-Related Mortality Among HIV/HCV Co-infected Patients: The Importance of Behaviors in the HCV Cure Era (ANRS CO13 HEPAVIH Cohort)

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