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HCV-Related Mortality Among HIV/HCV Co-infected Patients: The Importance of Behaviors in the HCV Cure Era (ANRS CO13 HEPAVIH Cohort)

dc.rights.licenseopenen_US
dc.contributor.authorSANTOS, M. E.
dc.contributor.authorPROTOPOPESCU, C.
dc.contributor.authorSOGNI, P.
dc.contributor.authorYAYA, I.
dc.contributor.authorPIROTH, L.
dc.contributor.authorBAILLY, F.
dc.contributor.authorMARCELLIN, F.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorESTERLE, Laure
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorWITTKOP, Linda
dc.contributor.authorROSENTHAL, E.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMORLAT, Philippe
dc.contributor.authorROUX, P.
dc.contributor.authorDE ARAUJO, W. N.
dc.contributor.authorSALMON-CERON, D.
dc.contributor.authorCARRIERI, M. P.
dc.date.accessioned2021-02-16T14:22:53Z
dc.date.available2021-02-16T14:22:53Z
dc.date.issued2020
dc.identifier.issn1573-3254 (Electronic) 1090-7165 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/26257
dc.description.abstractEnMortality among individuals co-infected with HIV and hepatitis C virus (HCV) is relatively high. We evaluated the association between psychoactive substance use and both HCV and non-HCV mortality in HIV/HCV co-infected patients in France, using Fine and Gray’s competing-risk model adjusted for socio-demographic, clinical predictors and confounding factors, while accounting for competing causes of death. Over a 5-year median follow-up period, 77 deaths occurred among 1028 patients. Regular/daily cannabis use, elevated coffee intake, and not currently smoking were independently associated with reduced HCV-mortality (adjusted sub-hazard ratio [95% CI] 0.28 [0.10–0.83], 0.38 [0.15–0.95], and 0.28 [0.10–0.79], respectively). Obesity and severe thinness were associated with increased HCV-mortality (2.44 [1.00–5.93] and 7.25 [2.22–23.6] versus normal weight, respectively). Regular binge drinking was associated with increased non-HCV-mortality (2.19 [1.10–4.37]). Further research is needed to understand the causal mechanisms involved. People living with HIV/HCV co-infection should be referred for tobacco, alcohol and weight control interventions and potential benefits of cannabis-based therapies investigated.
dc.language.isoENen_US
dc.subjectMORPH3Eus
dc.title.enHCV-Related Mortality Among HIV/HCV Co-infected Patients: The Importance of Behaviors in the HCV Cure Era (ANRS CO13 HEPAVIH Cohort)
dc.title.alternativeAIDS Behaven_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1007/s10461-019-02585-7en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed31286317en_US
bordeaux.journalAIDS and Behavioren_US
bordeaux.page1069-1084en_US
bordeaux.volume24en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue4en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamMORPH3Eusen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
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