LECAT, Nicolas; FOURRIER-REGLAT, Annie; MONTAGNI, Ilaria; TZOURIO, Christophe; PARIENTE, Antoine; VERDOUX, Helene; DAUBECH-TOURNIER, Marie

doi:10.1016/j.psychres.2020.113276

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LECAT, Nicolas
Bordeaux population health [BPH]

FOURRIER-REGLAT, Annie

Bordeaux population health [BPH]

MONTAGNI, Ilaria

Bordeaux population health [BPH]

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Psychiatry Research. 2020, vol. 291, p. 113276

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Aims To investigate the association between the use of anxiolytic/hypnotic drugs and suicidal thoughts and/or behavior (STB) in students. Methods 12,112 participants who completed the baseline questionnaire in the i-Share cohort between April 2013 and March 2017 were included. STB were defined at inclusion as suicidal thoughts over the previous year and/or a lifetime suicide attempt. The use of prescribed anxiolytic/hypnotic drugs over the previous 3 months was measured at baseline and follow-up time points (in 2,919 students). Psychiatric disorders were assessed through validated scales. Multivariate logistic regression models were run using disease risk score. Results At inclusion, 25.2% of students had STB and 10.3% used anxiolytics/hypnotics. STB at baseline were associated with a more frequent use of anxiolytics/hypnotics in the previous 3 months, after adjustment for covariates including anxiety, depression, sleep, impulsivity, and substance use. The use of anxiolytics/hypnotics at baseline was not associated with the occurrence, persistence or remission of STB one year later. STB at baseline were associated with a new anxiolytic/hypnotic treatment one year later. Conclusions Anxiolytic/hypnotic drug use was associated with STB in students independently of many risk factors of suicide and most psychiatric disorders that require such treatment, which raises drug safety concerns.< Réduire

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PharmacoEpi-Drugs

HEALTHY

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Association between anxiolytic/hypnotic drugs and suicidal thoughts or behaviors in a population-based cohort of students

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