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Association between anxiolytic/hypnotic drugs and suicidal thoughts or behaviors in a population-based cohort of students

dc.rights.licenseopenen_US
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorLECAT, Nicolas
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorFOURRIER-REGLAT, Annie
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMONTAGNI, Ilaria
ORCID: 0000-0003-0076-0010
IDREF: 258573880
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorTZOURIO, Christophe
IDREF: 69829209
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorPARIENTE, Antoine
IDREF: 13395711X
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorVERDOUX, Helene
IDREF: 115951903
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDAUBECH-TOURNIER, Marie
dc.date.accessioned2021-02-02T15:40:37Z
dc.date.available2021-02-02T15:40:37Z
dc.date.issued2020
dc.identifier.issn0165-1781en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/26097
dc.description.abstractEnAims To investigate the association between the use of anxiolytic/hypnotic drugs and suicidal thoughts and/or behavior (STB) in students. Methods 12,112 participants who completed the baseline questionnaire in the i-Share cohort between April 2013 and March 2017 were included. STB were defined at inclusion as suicidal thoughts over the previous year and/or a lifetime suicide attempt. The use of prescribed anxiolytic/hypnotic drugs over the previous 3 months was measured at baseline and follow-up time points (in 2,919 students). Psychiatric disorders were assessed through validated scales. Multivariate logistic regression models were run using disease risk score. Results At inclusion, 25.2% of students had STB and 10.3% used anxiolytics/hypnotics. STB at baseline were associated with a more frequent use of anxiolytics/hypnotics in the previous 3 months, after adjustment for covariates including anxiety, depression, sleep, impulsivity, and substance use. The use of anxiolytics/hypnotics at baseline was not associated with the occurrence, persistence or remission of STB one year later. STB at baseline were associated with a new anxiolytic/hypnotic treatment one year later. Conclusions Anxiolytic/hypnotic drug use was associated with STB in students independently of many risk factors of suicide and most psychiatric disorders that require such treatment, which raises drug safety concerns.
dc.language.isoENen_US
dc.subjectPharmacoEpi-Drugs
dc.subjectHEALTHY
dc.title.enAssociation between anxiolytic/hypnotic drugs and suicidal thoughts or behaviors in a population-based cohort of students
dc.title.alternativePsychiatry Resen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.psychres.2020.113276en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed32763539en_US
bordeaux.journalPsychiatry Researchen_US
bordeaux.page113276en_US
bordeaux.volume291en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamPharmacoEpi-Drugsen_US
bordeaux.teamHEALTHY_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03129139
hal.version1
hal.date.transferred2021-02-02T15:40:41Z
hal.exporttrue
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