LUNEMANN, S.; SCHOBEL, A.; KAH, J.; FITTJE, P.; HOLZEMER, A.; LANGENECKERT, A. E.; HESS, L. U.; POCH, T.; MARTRUS, G.; GARCIA-BELTRAN, W. F.; KORNER, C.; ZIEGLER, A. E.; RICHERT, Laura; OLDHAFER, K. J.; SCHULZE ZUR WIESCH, J.; SCHRAMM, C.; DANDRI, M.; HERKER, E.; ALTFELD, M.

doi:10.1053/j.gastro.2018.07.019

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LUNEMANN, S.

SCHOBEL, A.

KAH, J.

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Gastroenterology. 2018-11, vol. 155, n° 5, p. 1366-1371.e3

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Killer-cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer (NK) cells. Binding of KIR3DS1 to its recently discovered ligand, HLA-F, activates NK cells and has been associated with resolution of hepatitis C virus (HCV) infection. We investigated the mechanisms by which KIR3DS1 contributes to the antiviral immune response. Using cell culture systems, mice with humanized livers, and primary liver tissue from HCV-infected individuals, we found that the KIR3DS1 ligand HLA-F is up-regulated on HCV-infected cells, and that interactions between KIR3DS1 and HLA-F contribute to NK cell-mediated control of HCV. Strategies to promote interaction between KIR3DS1 and HLA-F might be developed for treatment of infectious diseases and cancer.< Réduire

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Interactions Between KIR3DS1 and HLA-F Activate Natural Killer Cells to Control HCV Replication in Cell Culture

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