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Interactions Between KIR3DS1 and HLA-F Activate Natural Killer Cells to Control HCV Replication in Cell Culture

dc.rights.licenseopenen_US
dc.contributor.authorLUNEMANN, S.
dc.contributor.authorSCHOBEL, A.
dc.contributor.authorKAH, J.
dc.contributor.authorFITTJE, P.
dc.contributor.authorHOLZEMER, A.
dc.contributor.authorLANGENECKERT, A. E.
dc.contributor.authorHESS, L. U.
dc.contributor.authorPOCH, T.
dc.contributor.authorMARTRUS, G.
dc.contributor.authorGARCIA-BELTRAN, W. F.
dc.contributor.authorKORNER, C.
dc.contributor.authorZIEGLER, A. E.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorRICHERT, Laura
dc.contributor.authorOLDHAFER, K. J.
dc.contributor.authorSCHULZE ZUR WIESCH, J.
dc.contributor.authorSCHRAMM, C.
dc.contributor.authorDANDRI, M.
dc.contributor.authorHERKER, E.
dc.contributor.authorALTFELD, M.
dc.date.accessioned2020-11-30T14:06:26Z
dc.date.available2020-11-30T14:06:26Z
dc.date.issued2018-11
dc.identifier.issn1528-0012 (Electronic) 0016-5085 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/21267
dc.description.abstractEnKiller-cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer (NK) cells. Binding of KIR3DS1 to its recently discovered ligand, HLA-F, activates NK cells and has been associated with resolution of hepatitis C virus (HCV) infection. We investigated the mechanisms by which KIR3DS1 contributes to the antiviral immune response. Using cell culture systems, mice with humanized livers, and primary liver tissue from HCV-infected individuals, we found that the KIR3DS1 ligand HLA-F is up-regulated on HCV-infected cells, and that interactions between KIR3DS1 and HLA-F contribute to NK cell-mediated control of HCV. Strategies to promote interaction between KIR3DS1 and HLA-F might be developed for treatment of infectious diseases and cancer.
dc.language.isoENen_US
dc.subject.enSISTM
dc.title.enInteractions Between KIR3DS1 and HLA-F Activate Natural Killer Cells to Control HCV Replication in Cell Culture
dc.title.alternativeGastroenterologyen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1053/j.gastro.2018.07.019en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed30031767en_US
bordeaux.journalGastroenterologyen_US
bordeaux.page1366-1371.e3en_US
bordeaux.volume155en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue5en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamSISTMen_US
bordeaux.teamSISTM_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
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