AUDEMARD, Juliette; CREUSOT, Nicolas; LELOUP, Julie; DUVAL, Charlotte; HALARY, Sébastien; GOT, Jeanne; MARIE, B; MARKOV, Gabriel; DIÉMÉ, Binta; FRIOUX, Clémence

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AUDEMARD, Juliette
Pleiade, from patterns to models in computational biodiversity and biotechnology [PLEIADE]

CREUSOT, Nicolas
Plateforme Bordeaux Metabolome
Ecosystèmes aquatiques et changements globaux [UR EABX]

LELOUP, Julie
Laboratoire d'Océanographie et du Climat : Expérimentations et Approches Numériques [LOCEAN]

Langue

Communication dans un congrès

Ce document a été publié dans

JOBIM 2025 - Journées Ouvertes en Biologie, Informatique et Mathématiques, 2025-07-08, Bordeaux. 2025-07-10

Résumé en anglais

Favored by global changes, freshwater cyanobacterial harmful blooms (HCBs) generate increasing ecological, economical and public health challenges. Microcystis, one the most pervasive genera of cyanobacteria, grows within a phycosphere where specialized interactions with its microbiome occurs, and are suspected to inﬂuence bloom appearance and its potential toxicity.Through metagenomic, metabolomic and metabolic modelling, we characterized twelve Microcystis phycosphere cultured after isolation from a French pond. Metagenomic revealed that associated bacteria introduce new functions to the phycosphere, while functional redundancy within and across communities remains. Metabolic reaction presence in Microcystis is consistent with their genospecies, whereas community-levelmetabolic landscape diverges cyanobacteria’s phylogeny. On the other hand, metabolomic results lean on metabolic output led by cyanobacteria. Metabolic modelling and identiﬁcation of toxic secondary metabolites biosynthetic gene cluster further highlighted differences between phycosphere metabolic capabilities and the importance of manual curation of secondary metabolism in GSMNs. These ﬁndings deepen understanding of Microcystis’ phycosphere functioning, demonstrate the relevance of multi-omics systems biology approaches, and lay the ground for further characterisation of freshwater HCB’s microbial interactions and inter-species complementarity.< Réduire

Mots clés en anglais

Freshwater cyanobacteria

Microcystin

Metabolic modelling

Microbial communities

Systems biology

Origine

Importé de hal

Unités de recherche

BioGeCo (Biodiversité Gènes & Communautés) - UMR 1202