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Metagenome-scale metabolic modelling for the characterization of cross-feeding interactions in freshwater cyanobacteria-associated microbial communities

hal.structure.identifierPleiade, from patterns to models in computational biodiversity and biotechnology [PLEIADE]
dc.contributor.authorAUDEMARD, Juliette
hal.structure.identifierPlateforme Bordeaux Metabolome
hal.structure.identifierEcosystèmes aquatiques et changements globaux [UR EABX]
dc.contributor.authorCREUSOT, Nicolas
hal.structure.identifierLaboratoire d'Océanographie et du Climat : Expérimentations et Approches Numériques [LOCEAN]
dc.contributor.authorLELOUP, Julie
hal.structure.identifierMuséum national d'Histoire naturelle [MNHN]
dc.contributor.authorDUVAL, Charlotte
hal.structure.identifierMuséum national d'Histoire naturelle [MNHN]
hal.structure.identifierMolécules de Communication et Adaptation des Micro-organismes [MCAM]
dc.contributor.authorHALARY, Sébastien
hal.structure.identifierDynamics, Logics and Inference for biological Systems and Sequences [Dyliss]
dc.contributor.authorGOT, Jeanne
hal.structure.identifierCentre National de la Recherche Scientifique [CNRS]
hal.structure.identifierMuséum national d'Histoire naturelle [MNHN]
dc.contributor.authorMARIE, B
hal.structure.identifierLaboratoire de Biologie Intégrative des Modèles Marins [LBI2M]
hal.structure.identifierStation biologique de Roscoff = Roscoff Marine Station [SBR]
dc.contributor.authorMARKOV, Gabriel
hal.structure.identifierMetaboHUB-Clermont
hal.structure.identifierUnité de Nutrition Humaine [UNH]
dc.contributor.authorDIÉMÉ, Binta
hal.structure.identifierPleiade, from patterns to models in computational biodiversity and biotechnology [PLEIADE]
dc.contributor.authorFRIOUX, Clémence
dc.date.created2025-07-10
dc.date.issued2025-07-10
dc.date.conference2025-07-08
dc.description.abstractEnFavored by global changes, freshwater cyanobacterial harmful blooms (HCBs) generate increasing ecological, economical and public health challenges. Microcystis, one the most pervasive genera of cyanobacteria, grows within a phycosphere where specialized interactions with its microbiome occurs, and are suspected to influence bloom appearance and its potential toxicity.Through metagenomic, metabolomic and metabolic modelling, we characterized twelve Microcystis phycosphere cultured after isolation from a French pond. Metagenomic revealed that associated bacteria introduce new functions to the phycosphere, while functional redundancy within and across communities remains. Metabolic reaction presence in Microcystis is consistent with their genospecies, whereas community-levelmetabolic landscape diverges cyanobacteria’s phylogeny. On the other hand, metabolomic results lean on metabolic output led by cyanobacteria. Metabolic modelling and identification of toxic secondary metabolites biosynthetic gene cluster further highlighted differences between phycosphere metabolic capabilities and the importance of manual curation of secondary metabolism in GSMNs. These findings deepen understanding of Microcystis’ phycosphere functioning, demonstrate the relevance of multi-omics systems biology approaches, and lay the ground for further characterisation of freshwater HCB’s microbial interactions and inter-species complementarity.
dc.language.isoen
dc.rights.urihttp://creativecommons.org/licenses/by/
dc.subject.enFreshwater cyanobacteria
dc.subject.enMicrocystin
dc.subject.enMetabolic modelling
dc.subject.enMicrobial communities
dc.subject.enSystems biology
dc.title.enMetagenome-scale metabolic modelling for the characterization of cross-feeding interactions in freshwater cyanobacteria-associated microbial communities
dc.typeCommunication dans un congrès
dc.subject.halInformatique [cs]/Bio-informatique [q-bio.QM]
bordeaux.conference.titleJOBIM 2025 - Journées Ouvertes en Biologie, Informatique et Mathématiques
bordeaux.countryFR
bordeaux.conference.cityBordeaux
bordeaux.peerReviewedoui
hal.identifierhal-05281552
hal.version1
hal.invitednon
hal.proceedingsnon
hal.conference.end2025-07-11
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-05281552v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.date=2025-07-10&rft.au=AUDEMARD,%20Juliette&CREUSOT,%20Nicolas&LELOUP,%20Julie&DUVAL,%20Charlotte&HALARY,%20S%C3%A9bastien&rft.genre=unknown


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